While zinc increases DHT through the testosterone route,it can also inhibit DHT production. The body uses an enzyme called 5-alpha-reductase to convert testosterone to DHT. Zinc blocks this enzyme’s activity which, in a way, also blocks DHT. It is a tricky situation here where it is hard...
Diseases caused by trypanosomatids include leishmaniasis (Leishmania spp.), Chagas disease (Trypanosoma cruzi), and sleeping sickness (Trypanosoma brucei) that affect millions of people, especially low-income populations, being classified as neglected tr
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel virus responsible for the current coronavirus disease 2019 (COVID-19) pandemic, has infected over 3.5 million people all over the world since the first case was reported from Wuhan, China 5 months ago. As more epidemiologica...
These properties became the starting point of a study on a drug that activates AMPK, PXL770, administered at a dose of 500 mg per day over 4 weeks of follow up. At the endpoint, the safety of PXL770 for use was proven, and the authors also observed improvements in insulin sensitivity ...
Specifically, PAI-1 inactivates urokinase-type plasminogen activator (UPA) and tissue-type plasminogen activator (TPA), preventing the conversion of plasminogen to plasmin [17]. However, the involvement of Lp(a) in the atherothrombotic burden has become a subject of debate in recent years. While...
The campylobacter jejuni CiaD effector protein activates MAP kinase signaling pathways and is required for the development of disease. Cell Commun Signal. 2013;11(1):79. doi: 10.1186/1478-811X-11-79 (Open in a new window)PubMed (Open in a new window)Web of Science ®(Open in a new...
The p53 pathway is composed of hundreds of genes and their products that respond to a wide variety of stress signals. These responses to stress include apoptosis, cellular senescence or cell cycle arrest. In addition the p53-regulated genes produce prote
Pablos MI, Reiter RJ, Ortiz GG, Guerrero JM, Agapito MT, Chuang JI et al (1998) Rhythms of glutathione peroxidase and glutathione reductase in brain of chick and their inhibition by light. Neurochem Int 32:9–75 Google Scholar Reiter RJ, Melchiorri D, Sewerynek E, Poeggeler B, Barlow...
On the other hand, PFKL is feedback activated by F1,6BP, which auto-activates enzyme performance. When samples from women who did not have a subsequent cancer recurrence were tested using anti-PFKL antibodies, PFKL was found in the nucleoli of tumor cells (Figure 4C), where it co-localize...
Insulin activates ATP-sensitive K(+) channels in pancreatic beta-cells through a phosphatidylinositol 3-kinase-dependent pathway. Diabetes 2001, 50, 2192–2198. [Google Scholar] [CrossRef] [PubMed] [Green Version] Hagren, O.I.; Tengholm, A. Glucose and insulin synergistically activate ...