biological function and signaling pathways involving EVH1 domainsSummary This chapter contains sections titled: Introduction Occurrence and Distribution of EVH1 Domains Proteins Containing EVH1 Domains Modular Architecture of EVH1-containing Proteins: Domain Location, Domain Combinations, and Copy Number ...
Summary This chapter contains sections titled: Introduction Occurrence and Distribution of EVH1 Domains Proteins Containing EVH1 Domains Modular Architecture of EVH1-containing Proteins: Domain Location, Domain Combinations, and Copy Number Classification of EVH1 Domains Structures of EVH1 Domains and Their Co...
RepA-WH1 is thus con- verted from a dimerization domain into a DNA binding module, ancillary to the major determinant of sequence-specific DNA binding (the C-terminal domain, WH2)12–15. Aiming to model ab initio protein amyloidogenesis within a synthetic minimal framework, rather than ...
In a first stage, we engineered RepA, a protein coded by plasmid pPS10, by deleting its C-terminal domain (WH2) thus leaving the N-terminal winged-helix domain (WH1)18. This decoupled DNA-promoted conformational transitions in RepA-WH1 from its natural role: ena- bling RepA as a DNA ...
and dynamics of the RepA-WH1 prionoid. This prion-like protein, a manifold domain from the plasmid replication protein RepA, itself capable of assembling a functional amyloid, causes when expressed inE. colia synthetic amyloid proteinopathy, the first model for an amyloid disease with a purely ...
An EVH1/WH1 domain as a key actor in TGFβ signalling EVH1 (enabled VASP (vasodilator-stimulated protein) homology 1)/WH1 (WASP (Wiskott–Aldrich syndrome protein) homology 1) domains, present in Ena VASP and ... I Callebaut - 《Febs Letters》 被引量: 53发表: 2002年 EVH1/WH1 domains ...