One of the obstacles to scaling up paediatric antiretroviral therapy (ART) coverage in resource-limited settings (RLS) is the relative complexity of paediatric dosing. There is a need to simplify ART in order to facilitate treatment initiation and ongoing management of infants and children by ...
Our objective was to evaluate the safety of TDF prescribed according to weight band dosing in treatment-experienced HIV-infected children. Methods: A prospective open-label study in HIV-infected children aged 3-18 years, weighing ≥ 15 kg and were receiving first-line regimen with virologic ...
The weight-band dosing regimen resulted in simulated exposures that were within the range demonstrated to be well tolerated and effective in the pivotal clinical trial and showed improved consistency in drug exposure across the achondroplasia population. Conclusions: The weight-band dosing regimen reduced...
Use of WHO paediatric weight-band dosing in drug labels.doi:10.1016/S2352-3018(21)00277-0Tom G JacobsDepartment of Pharmacy, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen 6525 GA, NetherlandsHylke Waalewijn...
Data are limited describing drug exposure/safety of lopinavir/ritonavir using WHO weight band dosing.Pinto, Jorge A.Capparelli, Edmund V.Warshaw, MeredithZimmer, BonnieCressey, Tim R.Spector, Stephen A.Qin, MinSmith, BetsySiberry, George K.Mirochnick, Mark...
Nikanjam M, Chadwick EG, Robbins B et al. Assessment of lopinavir pharmacokinetics with respect to developmental changes in infants and the impact on weight band-based dosing. Clin Pharmacol Ther 2012; 91: 243-9.Nikanjam M, Chadwick EG, Robbins B, et al. Assessment of lopinavir ...
Assessment of lopinavir pharmacokinetics with respect to developmental changes in infants and the impact on weight band-based dosing. Clin Pharmacol Ther. Feb 2012;91(2):243-249. Available at http://www.ncbi.nlm.nih.gov/pubmed/22190064....
Nikanjam M, Chadwick EG, Robbins B, et al. Assessment of lopinavir pharmacokinetics with respect to developmental changes in infants and the impact on weight band-based dosing. Clin Pharmacol Ther. Feb 2012;91(2):243-249. Available at http://www.ncbi.nlm.nih.gov/pubmed/22190064....