Therefore, supplementing with leptin can bring about energy balance and result in weight loss. (7) More research is needed on the effectiveness of leptin. Advertisements Neuropeptide Y Neuropeptide Y (NPY) naturally exists in the nervous system and is produced in relation to leptin. While leptin...
Leptin acts on hypothalamic neurons expressing agouti-related protein (AgRP) or pro-opiomelanocortin (POMC) to suppress appetite and increase energy expenditure, but the intracellular mechanisms that modulate central leptin signalling are not fully understood. Here we show that growth factor receptor-bound...
in 1994 (1), dysregulation of leptin or its receptors has been implicated in several models of obesity. Both systemic and intracranial injections of leptin result in the suppression of food intake and body weight as well as an increase in metabolic rate. Spinedi and Gaillard (6) first ...
Here we show that growth factor receptor-bound protein 10 (Grb10), an adaptor protein that binds to the insulin receptor and negatively regulates its signalling pathway, can interact with the leptin receptor and enhance leptin signalling. Ablation of Grb10 in AgRP neurons promotes weight gain,...
Intracerebroventricular (ICV) injections of leptin decrease food intake and body weight while increasing energy expenditure. Some of these effects are reportedly enhanced in bilaterally adrenalectomized (ADX) rats. The purpose of the present experiment was to establish the time course of the suppressi...
A.Exploring ways of losing weight.B.Tracking the history of weight loss.C.Treating obesity-linked inflammation.D.Boosting interest in anti-obesity drugs. 免费查看参考答案及解析 题目: Teasing Kids About Their Weight May Make Them Gain MoreSchool can be tough on kids who have overweight or ...
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This study examined whether leptin (LP) injections following a weight reduction in diet-induced obese rats would reduce both the enhanced food intake and body weight (BW) regain typically seen in weight reduced animals after a weight reduction. Also, the findings of the current study were ...
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injections of leptin (0.3 g/g and 1.0 g/g) to neonatal rats led to a significant reduction in weight gain over 10 d compared with the control group (p Ͻ 0.01 and p Ͻ 0.01, respectively). Concomitant with a reduction in weight gain, retroperitoneal fat pad weight also ...