Aim: To describe the anticoagulant effect, as assessed by initial activated partial thromboplastin time (APTT) result and time taken to reach the target APTT range, using a weight-based heparin protocol. A secondary aim was to assess the level of concordance with the protocol. Method: Records ...
Evaluation of A Simplified Weight-Based Heparin Dosing Protocol in Patients With Unstable Ischemic SyndromesHoney, Tami N.; Laine, Greg A.; Puckett, William H.Abstract An abstract is unavailable. This article is available as HTML full text only....
Heparin therapy improves clinical outcomes in patients with thromboembolic disorders [1-4], but the determination of appropriate heparin dosing is often problematic. Physicians' dosing decisions vary widely, as do their therapeutic goals [5]. Practice audits reveal frequent underdosing, with delays in...
The weight-based heparin dosing nomogram compared with a "standard care" nomogram. Ann Intern Med. 1993;119874- 881Google ScholarCrossref 30. Hull RDRaskob GERosenbloom D et al. Optimal therapeutic level of heparin therapy in patients with venous thrombosis. Arch Intern Med. 1992;1521589- ...
Saya FG, Coleman LT, Martinoff JT (1985) Pharmacist-directed heparin therapy using a standard dosing and monitoring protocol. Am J Hosp Pharm 42:1965–1969 CAS PubMed Google Scholar Rivey MP, Peterson JP (1993) Pharmacy-managed, weight-based heparin protocol. Am J Hosp Pharm 50:279–284...
Site-specific validation of the activated partial thromboplastin time (aPTT) therapeutic range is required to ensure administration of the optimal dose of unfractionated heparin. Therapeutic ranges of 1.5 to 2.5 times the control value are subtherapeutic for most modern aPTT reagents.To audit the approp...
Low-molecular-weight heparin (LMWH), derived from unfractionated heparin (UFH), has enhanced anticoagulant efficacy, long duration of action, and extended half-life. Patients receiving LMWH for preventive therapies would strongly benefit from its long-te
This unfractionated heparin dosing, however, was not associated with a reduction in the rate of intracranial hemorrhage, by contrast with the findings of a recent post-hoc analysis of the Intravenous tPA for the Treatment of Infarcting Myocardium Early (InTIME)-II data. Guigliano et al., Am....
Development of institution-specific weight-based heparin dosing protocol for treatment of venous thromboembolic diseaseRivkin, KLyakhovetskiy, ASiviglia, GKanna, BBerger, R
Small studies have recommended smaller dosing of unfractionated heparin (UFH) in obese patients. Methods: The primary objective of this study was to compare the rate of achieved therapeutic aPTT within 24 hours of initiating a weight-based UFH drip per protocol between obese and non-obese pati...