供货周期 现货规格 10 mM * 1 mL 货号 HY-133121应用领域 医疗卫生,化工,生物产业,制药 WDR5-IN-1 是一种有效的选择性 WD 重复结构域 5 (WDR5) 抑制剂,Kd 为 50为 2.2 nM。WDR5-IN-1 减少 WDR5 移位基因的 MYC 募集,并在 CHP-134 (神经母细胞瘤) 和 Ramos (Burkitt淋巴瘤) 细胞系中显示出有...
WDR5-IN-1 | MedChemExpress(MCE) 英文名称: 总访问: 82 国产/进口: 进口 半年访问: 18 产地/品牌: MedChemExpress(MCE) 产品类别: 生化试剂 规格: 电询 最后更新: 2025-2-13 货号: HY-133121 CAS 号: 2408842-51-1 参考报价: 电询 立即询价 电话咨询 ...
WDR5-IN-1 | MedChemExpress 英文名称: 总访问: 41 国产/进口: 进口 半年访问: 2 产地/品牌: Medchemexpress (MCE) 产品类别: 生化试剂 规格: 100 mg; 250 mg; 500 mg 最后更新: 2024-11-4 货号: HY-133121 CAS 号: 2408842-51-1 参考报价: 询价 立即询价 电话咨询 ...
WDR5-MYC-IN-1(compound 4o)作为WDR5-MYC相互作用的抑制剂,展现出了高效性,具有1.0 µM的Ki值,并显示出了抗增殖的活性.
Product NameMETTL1-WDR4-IN-2 CAS2919742-07-5 CBNumberCB914274869 MFC24H23N5O6S MW509.54 MOL File2919742-07-5.mol Chemical Properties Boiling point887.290±75.00 °C(Press: 760.00 Torr)(predicted) Density1.671±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) ...
CAS号: 2919742-07-5 英文名: METTL1-WDR4-IN-2 英文别名: METTL1-WDR4-IN-2 中文名: 化合物 METTL1-WDR4-IN-2 中文别名: 化合物 METTL1-WDR4-IN-2 CBNumber: CB914274869 分子式: C24H23N5O6S 分子量: 509.54 MOL File: 2919742-07-5.mol 化学...
Replacement of Arg-3765 with alanine in the MLL1 Win motif abolishes the interaction between MLL1 and WRAD and the H3K4me2 activity of the MLL1 core complex in vitro (36). The significance of the interaction between the Win motif and WDR5 in cells is highlighted by the evolutionarily ...
RNAi-mediated attenuation of WDR5 upregulated expression of wild-type but not mutant p53, an effect associated with growth inhibition and apoptosis. Similarly, a small-molecule antagonist of WDR5 reduced N-Myc/WDR5 complex formation, N-Myc target gene expression, and cell growth in neuroblastoma...
Finally, we further verified our conclusions in spontaneous tumor formation mouse MMTV-PyMT and nude mouse orthotopic transplantation tumor models. Results METTL3 was found to bind mainly to c-Myc/WDR5 protein in the nucleus. It enhances the stability of c-Myc/WDR5 interaction through its ...
объем: 0,7 л, 1 л, 2 л, 5 л, 10 л, 30 л...; типпродукта:четырехугольный, круглый, специальныйиквадратныйострый; сертиф...