构建裸鼠皮下异种移植瘤进行体内验证,转染si-WDFY3-AS2可抑制体内肿瘤生长.mi R-139-5p inhibitor或过表达SDC4可以恢复沉默lnc RNA WDFY3-AS2对肿瘤生长的抑制作用.第三部分,华蟾素增强A2780-DDP对顺铂敏感性,抑制侵袭迁移能力,下调干细胞表型,限制成球能力.华蟾素下调A2780-DDP中lnc RNA WDFY3-AS2的水平,...
WDFY3-AS2 was predicted to impact OC by sponging miR-139-5p and regulating SDC4. The xenografts inoculated with A2780-DDP cells additionally confirmed that tumor growth in vivo was reduced by si-WDFY3-AS2 transfection. MiR-139-5p inhibitor or SDC4 overexpression could restore the suppressive ...
Kaplan鈥揗eier analysis found that patients with high WDFY3-AS2 expression had longer OS than the low expression ones in the stratified cohorts. Additionally, GO and GSEA showed that gene sets correlated with WDFY3-AS2 expression were involved in regulation of synaptic transmission, glutamate ...
lncRNA WDFY3‐AS2microRNA‐18amigrationovarian cancerproliferationRORAOvarian cancer (OC) is a fatal cancer in women, mainly due to its aggressive nature and poor survival rate. The lncRNA﹎iRNA﹎RNA (long noncoding RNA﹎icroRNA﹎essenger RNA) interaction is promising biomarkers for the improving...
WDFY3‐AS2ZNF703Lung adenocarcinoma (LUAD) is one of the most common diagnosed pathological categories of lung cancer. Long noncoding RNAs (lncRNAs) have been manifested to be key regulators in modulating multiple cancers. Nevertheless, the pathologic role of lncRNA WDFY3〢S2 in LUAD remains ...
Univariate and multivariate Cox regression analysis showed that lower expression of WDFY3‐AS2 and TIMP3 was significantly related to tumor grade, tumor size, lymph node metastasis, distant metastasis, and TNM stage. The expression of TIMP3 in KIRC tissues was also verified by immunohistochemistry, ...