Binding of cytochrome c, released from the damaged mitochondria, to the apoptotic protease activating factor 1 (Apaf-1) is a key event in the apoptotic signaling cascade. The binding triggers a major domain rearrangement in Apaf-1, which leads to oligome
Interactions on the interface between cytochromecand Apaf-1 in the PatchDock’ model (this work) and the cryo-EM based model [PDB:3J2T] [25]. Cytochromecis shown in cyan, the WD domains of Apaf-1 in the PatchDock’ model are shown in pink, the WD domains in the cryo-EM based model...
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In this work, we have combined several molecular modeling approaches to scrutinize the interaction between the human cytochromecand the WD domains of Apaf-1. We were encouraged by recent results of Kokhan, Wraight and Tajkhorshid [42] who have studied the interaction between the yeast cytochromecan...