Tryptophan-aspartate 40 repeat-containing (WD40 repeat, WD repeat, or WDR) proteins are a large and broadly distributed protein family. The WD40 domain has multiple copies of WD40 repeats that fold into highly conserved anti-parallel β-sheet, propeller tertiary structure. Approximately 600 human...
27,28,29. Besides the divergence of conserved WD40 repeat domains, the protein encoded by mango WD40 gene family were significantly varied in the numbers of amino acids, physicochemical properties and divergence in the subcellular localization within a cell (Supplementary...
It was estimated that WD40 domain-containing proteins (WD40 protein family) account for about 1% of the human proteome1. A canonical WD40 domain comprises 7 blades or repeats, each of which contains 40–60 residues with a motif of WD (tryptophan and aspartic acid). The blades then fold ...
Here, we reveal that WDR26, a member of the WD40 repeat protein family, directly bound free Gbetagamma in vitro, and formed a complex with endogenous Gbetagamma in Jurkat T cells stimulated by the chemokine SDF1alpha. Suppression of WDR26 by siRNAs selectively inhibited Gbetagamma-dependent...
the WD40 repeat (WDR) domain, which has a central peptide-binding pocket and is a member of the β-propeller domain-containing protein family. Recently, two WDR domain-containing proteins, WDR5 and EED, as well as other β-propeller domains have been successfully targeted by potent, specific...
WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A. J Biol Chem. 2000; 275: 5257–63. Google Scholar11. Moreno, C.S... HL Ma,YL Peng,L Gong,... - 《Gene Regulation & ...
As an ancient protein family, the WD40 repeat proteins often play essential roles in fundamental cellular processes in eukaryotes. Although investigations of eukaryotic WD40 proteins have been frequently reported, prokaryotic ones remain largely uncharacterized. In this paper, we report a systematic ...
Picea abies nucleotide binding WD-40 repeat family protein (WD40) mRNA, partial cds 来自 ResearchGate 喜欢 0 阅读量: 17 作者:IA Yakovlev,DKA Asante,CG Fossdal,O Johnsen,O Junttila 摘要: We are studying 4 chromatin modifications H3K4me3; H3K27me3; H3K9me3, and H2A.Z in Norway spruce ...
Here, we further addressed Gq regulation of SphK1 by analysing the influence of the WD40 repeat protein, WDR36. WDR36 has been described as a scaffold tethering Gαq to phospholipase C (PLC)-β and the thromboxane A2 receptor-β (TPβ receptor). Overexpression of WDR36 in HEK-293 ...