Here, we reveal that WDR26, a member of the WD40 repeat protein family, directly bound free Gβγ in vitro , and formed a complex with endogenous Gβγ in Jurkat T cells stimulated by the chemokine SDF1α. Suppression of WDR26 by siRNAs selectively inhibited Gβγ-dependent phospholipase...
Here, we review one of the most abundant PPI domains in the human proteome, the WD40 repeat (WDR) domain, which has a central peptide-binding pocket and is a member of the β-propeller domain-containing protein family. Recently, two WDR domain-containing proteins, WDR5 and EED, as well...
Tryptophan-aspartate 40 repeat-containing (WD40 repeat, WD repeat, or WDR) proteins are a large and broadly distributed protein family. The WD40 domain has multiple copies of WD40 repeats that fold into highly conserved anti-parallel β-sheet, propeller tertiary structure. Approximately 600 human...
Here, we review one of the most abundant PPI domains in the human proteome, the WD40 repeat (WDR) domain, which has a central peptide-binding pocket and is a member of the β-propeller domain-containing protein family. Recently, two WDR domain-containing proteins, WDR5 and EED, as well...
It was estimated that WD40 domain-containing proteins (WD40 protein family) account for about 1% of the human proteome1. A canonical WD40 domain comprises 7 blades or repeats, each of which contains 40–60 residues with a motif of WD (tryptophan and aspartic acid). The blades then fold ...
Background The receptor for activated C-kinase 1 (RACK1) is a conserved protein belonging to the WD40 repeat family of proteins. It folds into a beta prope... N Omosigho,K Swaminathan,M Plomann,... - 《Cell Communication & Signaling》 被引量: 14发表: 2014年 WDR26 functions as a ...
Title: Targeting WD Repeat-Containing Protein 5 (WDR5): A Medicinal Chemistry Perspective. Authors: Chen X, Xu J, Wang X, Long G, You Q, Guo X. Abstract: WD repeat-containing protein 5 (WDR5) is a member of the WD40 protein family, and it is widely involved in various biological ...
they act as a scaffold for protein–protein or protein–DNA interaction. So far, no WD40 domain has been identified with intrinsic enzymatic activity. Several WD40 domain-containing proteins have been recently characterized in prokaryotes as well. The review summarizes the vast array of functions ...
《WD40重复蛋白家族的结构与热点氨基酸预测与药物设计》是吴云东为项目负责人，北京大学为依托单位的重点项目。科研成果 项目摘要 WD40重复蛋白家族占真核生物总体蛋白种类的1%，是最大的蛋白质家族之一，其主要功能是通过蛋白质-蛋白质相互作用组装各种不同的蛋白复合体，参与调控几乎所有的生物学功能。WD40重复蛋白有...