DNA, which is the coding molecule, is housed in the nucleus of eukaryotes and the cytoplasm of prokaryotes and is used to make RNA molecules in the process of transcription. RNA molecules travel to the ribosome, where functional proteins are c...
drugs based on nucleic acids — namely DNA andRNA, the vital information-carrying molecules — can control the biological functions of cells and are expected to transform the future of medicine and provide a significant boost towards efforts to overcome cancer and other ...
Our proposed ECL biosensor provided a highly sensitive detection of miRNA-21 with a detection limit of 96 aM ranging from 100 aM to 1 nM. Furthermore, this ECL sensing system was able to successfully distinguish the target RNA from its homologous family and presented a promising response in ...
there is an ever-growing interest in liquid biopsies and circulating tumour DNA (ctDNA) based NGS analyses. CtDNA can identify discordant alterations compared to tissue biopsies, including subclonal drivers of resistance to therapy. Its use could offer access to further targeted therapies even in ...
RNA-binding protein EWS STAG2: STAG2 cohesin complex component TP53: Tumor protein 53 CDKN2A: Cyclin-dependent kinase inhibitor 2 A KDR: Kinase insert domain receptor STK11: Serine/threonine kinase 11 MLH1: DNA mismatch repair protein Mlh1 KRAS: Kirsten rat sarcoma virus PTPN11: Tyro...
At genus level, the differences between donor did not enable to distinguish the potential effect of the arsenolipid treatments. However, Faecalibacterium genus (p = 0.038, q = 0.99) and Lachnospiraceae UCG-004 group (p = 0.050, q = 0.99) were reduced by arsenolipids treatment (Fig...
exactly, protein species - which are usually strongly interrelated based on their amino acid sequence, but which can, nonetheless, differ sometimes quite dramatically in chemical structure as a result of alternative splicing at the RNA and protein level [27] and/or due to post-translational ...
23 February 2018 / Published online: 19 March 2018 © The Author(s) 2018 Abstract Multiple sequence alignments are an essential tool in bioinformatics and computational biology, where they are used to represent the mutual evolutionary relationships and similarities between a set of DNA, RNA, or ...
Using their CyTOF approach, the authors longitudinally analyzed the immunometabolism of the transferred CD8+ T cells and observed an analogous but slightly earlier transient surge of Tea cells with increased metabolic activities compared to the endogenous counterparts. Interestingly, between days 4 and 5...
Mitochondrial division is not an autonomous event but involves multiple organelles, including the endoplasmic reticulum (ER) and lysosomes. Whereas the ER drives the constriction of mitochondrial membranes, the role of lysosomes in mitochondrial division