DNA, which is the coding molecule, is housed in the nucleus of eukaryotes and the cytoplasm of prokaryotes and is used to make RNA molecules in the process of transcription. RNA molecules travel to the ribosome, where functional proteins are c...
drugs based on nucleic acids — namely DNA andRNA, the vital information-carrying molecules — can control the biological functions of cells and are expected to transform the future of medicine and provide a significant boost towards efforts to overcome cancer and other ...
Our proposed ECL biosensor provided a highly sensitive detection of miRNA-21 with a detection limit of 96 aM ranging from 100 aM to 1 nM. Furthermore, this ECL sensing system was able to successfully distinguish the target RNA from its homologous family and presented a promising response in ...
there is an ever-growing interest in liquid biopsies and circulating tumour DNA (ctDNA) based NGS analyses. CtDNA can identify discordant alterations compared to tissue biopsies, including subclonal drivers of resistance to therapy. Its use could offer access to further targeted therapies even in ...
At genus level, the differences between donor did not enable to distinguish the potential effect of the arsenolipid treatments. However, Faecalibacterium genus (p = 0.038, q = 0.99) and Lachnospiraceae UCG-004 group (p = 0.050, q = 0.99) were reduced by arsenolipids treatment (Fig...
throughput, speed and breadth to identify molecular alterations in entire genomes or targeted regions of DNA or RNA. It is the basis for the identification of the majority of current druggable alterations and offers a unique window into novel alterations, and de novo and acquired resistance ...
exactly, protein species - which are usually strongly interrelated based on their amino acid sequence, but which can, nonetheless, differ sometimes quite dramatically in chemical structure as a result of alternative splicing at the RNA and protein level [27] and/or due to post-translational ...
Using their CyTOF approach, the authors longitudinally analyzed the immunometabolism of the transferred CD8+ T cells and observed an analogous but slightly earlier transient surge of Tea cells with increased metabolic activities compared to the endogenous counterparts. Interestingly, between days 4 and 5...
Rather, CTC clusters arise when a group of malignant cells detaches from a solid tumor deposit and enters into the blood circulation. By color-coding primary tumor cells to distinguish single versus clustered CTCs, it was also shown that even though single CTCs are more frequent in blood ...
Through the detection of disease information, including genes, proteins, and metabolites, it can accurately distinguish individual differences between tumours to improve the accuracy of tumour treatment while simultaneously enhancing the prediction and prevention of tumour risks. The long-term goal...