Serine-based β-lactamases of Class A, C and D all rely on a key water molecule to hydrolyze and inactivate β-lactam antibiotics. This process involves two conserved catalytic steps. In the first acylation step, the β-lactam antibiotic forms an acyl-enzyme intermediate (ES*) with the catal...
Fig. 2: Temperature evolution of relaxational absorption band. aTemperature dependences of the real part of the dielectric permittivityε′ of a hydrous cordierite crystal forE||apolarization at different frequencies as indicated. In addition,ε′(T) data for a water-free cordierite crystal (WF, ...
In order to predict the potencies of mechanism-based reversible covalent inhibitors, the relationships between calculated Gibbs free energy of hydrolytic water molecule in acyl-trypsin intermediates and experimentally measured catalytic rate constants (k cat ) were investigated. After obtaining representative...
1 c). Such a dynamic is a characteristic of individual emitters and is typically found in single molecule fluorescence 18., 19.. We also noticed that the brightness of each individual cluster and the number of clusters located in the field of view increased during the first 10 min of ...
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4) [44,45] and 1440 and 1452 nm, i.e., C07-C08 that are known as the bands of water hydration [35] and water molecule connected to another water molecule (S1) [14,46] and the symmetric and asymmetric stretching of first overtone of water [35,46,47]. However, in the range ...
The H2O molecule is electrically neutral, but the positive and negative charges are not distributed uniformly. This is illustrated by the gradation in color in the schematic diagram here. The electronic (negative) charge is concentrated at the oxygen end of the molecule, owing partly to the non...
The irreversibly adsorbed water in shale samples is presumably held tightly within the shale micropore space by the strong interaction between the adsorbed water molecule and the pore wall. The intrinsic mechanism for the observed hysteresis loops involves hydrogen bonding to some OFGs (Gregg and ...
In places where the same molecule presented different trimethylsilyl (tms) derivatives with similar patterns of change, only one representative of the group was shown. When there was no agreement in the behavior of the different tms derivatives, we presented both metabolites (e.g., Phe 1tms and...
Mg is thought to be relocated from the older to the younger leaves enabling the plant to start the generative phase in order to finish its life cycle. One of the major functions of Mg in plants is its role as the central atom of the chlorophyll molecule in the light absorbing complex of...