vitamin KwarfarinanticoagulationWarfarin and other 4﹉ydroxycoumarins are effective antithrombotic agents. They affect four blood coagulation proteins that act sequentially to produce thrombin. Coumarin therapy decreases the biological activity of these proteins, and therefore decreases the rate at which ...
Vitamin K/warfarin interaction: Decreased INR in an elderly patient taking a multivitamin: case reportBlood-coagulation-disordersDrug-interactionsElderlyVitamin-K, drug interactionsWarfarin, drug interactions
Vitamin K & warfarin (Coumadin) - Warfarin (Coumadin) patients should have a healthy, consistent intake of vitamin K in their diets.
Vitamin K epoxide reductase (VKOR) catalyzes the reduction of vitamin K quinone and vitamin K 2,3-epoxide, a process essential to sustain gamma-carboxylation of vitamin K-dependent proteins. VKOR is also a therapeutic target of warfarin, a treatment for thrombotic disorders. However, the structu...
As the mechanism by which these drugs act has become clear, it has also been found that vitamin K will overcome the effects of coumarin anticoagulation and can be used to control bleeding side effects of coumarin therapy. Vitamin K is necessary for activity of a liver enzyme, the vitamin K...
Additional adverse effects such as necrosis, purple toe syndrome, osteoporosis, valve and artery calcification, and drug interactions have also been documented with warfarin use. Warfarin does not actually affect blood viscosity, rather, it inhibits vitamin-k dependent synthesis of biologically active ...
We knew that phylloquinone oxide had approximately the same activity as vitamin K 1 in vitamin K deficient rats but was ineffective in those treated with warfarin 2 . Evidence that the activity of the oxide was due to its conversion to vitamin K 1 , a reaction inhibited by warfarin in ...
Warfarin resistance is associated with a protein component of the vitamin K 2,3-epoxide reductase enzyme complex in rat liver. Warfarin, the most used drug in the world in long-term anticoagulation prophylaxis, targets the vitamin K 2,3-epoxide reductase (VKOR) of the vitamin K cyc... D ...
虽然寂寞总是我的朋友,但我不会对您不抱希望![translate] along-standing vitamin K deficiency or the ingestion of warfarin and some wide-spectrum antibiotics 耐久维生素K缺乏或杀鼠灵和一些宽光谱抗生素的摄取[translate]
Methods: Sixty-five patients with stable anticoagulation were... Y Zhu,M Shennan,KK Reynolds,... - 《Clinical Chemistry》 被引量: 384发表: 2007年 The effect of dietary vitamin K on warfarin-induced anticoagulation We examined the effect of vitamin-K-rich vegetables, vitamin-K-poor vegetables...