Self- monitoring may be appropriate in some patients. ◊ General references. 1. Harrington R, Ansell J. Risk-benefit assessment of anticoagulant therapy. Drug Safety 1991; 6: 54–69. 2. Le DT, et al. The international normalized ratio (INR) for moni- toring warfarin therapy: reliability...
however, found an increase in prothrombin time. the effect of cimetidine on warfarin appears to be dose-dependent6 and to be subject to interindividual variation;8·9 careful monitoring is needed. limited evidence suggests that cimetidine has a similar effect on the metabolism of acenocoumarojl0...