The objective of this study was to determine whether two vitamin K epoxide reductase complex 1 (VKORC1) polymorphisms contribute to the variability in warfarin response, particularly in African Americans. The effect of the VKORC1 1173C/T and -1639G/A polymorphisms was examined in a prospective...
Vitamin K epoxide reductase (VKOR) catalyzes the reduction of vitamin K quinone and vitamin K 2,3-epoxide, a process essential to sustain gamma-carboxylation of vitamin K-dependent proteins. VKOR is also a therapeutic target of warfarin, a treatment for thrombotic disorders. However, the structu...
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Coumarin therapy decreases the biological activity of these proteins, and therefore decreases the rate at which blood clots. As the mechanism by which these drugs act has become clear, it has also been found that vitamin K will overcome the effects of coumarin anticoagulation and can be used to...
Vitamin K & warfarin (Coumadin) - Warfarin (Coumadin) patients should have a healthy, consistent intake of vitamin K in their diets.
The effect of dietary vitamin K on warfarin-induced anticoagulation We examined the effect of vitamin-K-rich vegetables, vitamin-K-poor vegetables and phytomenadione on the stability of warfarin-induced anticoagulation. Pat... F.,M.,PEDERSEN,... - 《Journal of Internal Medicine》 被引量: 178发...
:a crystalline anticoagulant coumarin derivative C19H16O4that inhibits the production ofprothrombinby vitamin K and is used as a rodent poison and in medicine also:its sodium salt C19H15NaO4used especially in the prevention or treatment of thromboembolic disease ...
Balancing warfarin and vitamin K Objective: To examine an inflammatory effect of warfarin and comparing with IL-6 levels along with different demographic and clinical variables. THE IL-6 DEPENDENT EFFECT OF ORAL WARFARIN IN HEART VALVE REPLACEMENT PATIENTS BY MEASURING INTERACTING CLINICAL AND DEMOGRAPHI...
After discontinuation of warfarin and celecoxib, fresh frozen plasma and vitamin K were administered to normalize INR. The patient was not rechallenged. DISCUSSION: Warfarin is an oral anticoagulant with numerous reports of drug interactions. It is possible that other drug therapies or disease states...
R Lasseur,C Longin-Sauvageon,B Videmann,... - 《Journal of Biochemical & Molecular Toxicology》 被引量: 101发表: 2006年 Mechanism of coumarin action: sensitivity of vitamin K metabolizing enzymes of normal and warfarin-resistant rat liver The in vitro effects of two coumarin anticoagulants, wa...