This chapter summarises the most important principles of sleep physiology and pharmacology, which hopefully will help the clinician to understand how sleep and wakefulness are affected not only by neurological disorders, but also by their medical treatment. The bulk of current hypnotic medication, ...
Although traditionally stimulants, such as methylphenidate and dextroamphetamine, were used, first-line therapy now consists of the nonstimulant medication modafinil. Modafinil has a low potential for abuse, is well tolerated, and was effective in promoting wakefulness in clinical trials.61,62 Sodium ...
In particular, researchers have found that performance on the MATB tracking task (not tested here), as well as RT on the SYSMON task, and ACC on the COMM task were significantly affected by fatigue caused by either prolonged wakefulness or medication that induces similar effects [10,11,[14]...
a pain complaint with ESS, and a higher apnea/hypopnea index with MSLT. However, no associations were found between both objective and subjective sleepiness, and measures of motor disability, disease onset, medication (type and
Try months. There’s a genetic disease calledFatal Familial Insomnia. Basically a mutation progressively causes you to get less and less sleep until you are unable to fall alseep at all (Sleeping pills and medication are useless). You degenerate over the course of several months and then die....
Sudden uncontrollable somnolence and medication use in Parkinson disease. Arch Neurol 62: 1242–1248. Article Google Scholar Berry MD (2007). The potential of trace amines and their receptors for treating neurological and psychiatric diseases. Rev Recent Clin Trials 2: 3–19. Article CAS Google...
In Study 3, 5 narcoleptic patients on medication spent 2 nonconsecutive nights sleeping in the laboratory before completing the MSLT or RTSW throughout the next day. Results of the studies indicate that the latency to sleep onset under conditions of normal nocturnal sleep can be manipulated by ...
On the second active-treatment day the attending physician judged his symptoms to be possibly related to the study medication and he was disempaneled. A second participant, who was a rock guitarist, reported that tinnitus, which he had experienced intermittently before study enrollment, worsened ...
The Amaze Program will be evaluating Mazindol ER as an investigational once-daily oral medication to reduce occurrence of cataplexy and improve wakefulness. What is Narcolepsy Narcolepsy is a rare chronic neurological disorder characterized by Excessive Daytime Sleepiness (EDS). This symptom consists of...
Frightening dream episodes Occur in the REM stages Last about 20 minutes Can be result of taking drugs that affect neurotransmitter action or from drug withdrawal Severe cases can be treated with medication Diazepam (tranquilizer) Nightmares