Nuvo Pharmaceuticals (Ireland). These medications, used to improve wakefulness in patients with narcolepsy, obstructive sleep apnea, or shift work sleep disorder, mark a strategic move to grow Apotex’s US specialty business. The acquisition
Schweitzer P. Drugs that disturb sleep and wakefulness. Philadelphia: Elsevier Saunders; 2005.Schweitzer PK. Drugs that disturb sleep and wakefulness. In: Kryger MH, Roth T, Dement WC, eds. Principles and Practice of Sleep Medicine. 3rd ed. Philadelphia, Pa: WB Saunders; 2000: 441-461....
USA) at 0.03 mg/kg and raclopride (Sigma, USA) at 2 mg/kg were freshly prepared and i.p. administered at 15 min before CNO administration. All of the drugs were injected at a volume of 10 ml/kg of body weight.
Chakravorty SS, Rye DB. Narcolepsy in the older adult: Epidemiology, diagnosis and management. Drugs Aging. 2003;20(5):361-376. Chen L, Ho CK, Lam VK, et al. Interrater and intrarater reliability in multiple sleep latency test. J Clin Neurophysiol. 2008;25(4):218-221. Chesson AL Jr...
Is it primarily sleep deprivation? Or is there an influence of the sedative drugs administered in the first days, or of certain medical conditions? How and how fast can it be reversed? Answers to these questions may lead to changes in how mechanically ventilated patients are managed in the IC...
Drugs that increase extracellular dopamine by inhibiting dopamine transporter promote arousal22. Also, we recently found that VTA dopaminergic neurons are involved in the generation and maintenance of wakefulness11. As LC neurons secrete both NE and dopamine8,9,10, we applied in vivo CRISPR/Cas9 tec...
Stimulant drugs (dopamine and norepinephrine) can aid Periodic Limb Movement Disorder Involuntary movement of legs and sometimes arms occurring every 20-30 seconds, typically in NREM REM behavior disorder Vigorous movements in REM sleep acting out dream content Night Terrors abrupt awakenings with panic...
Although adequate sleep is essential to maintain the effectiveness of aircrew during military operations, the potential of drugs to sustain vigilance must also be considered. Beneficial changes in alertness may be achieved through the selective modulation of the activity of neurotransmitters involved in th...
wakefulness, which occurred twice as often in the placebo-treated participants as in the modafinil-treated participants and which may have benefitted the former. It is also possible that while both caffeine and modafinil are largely effective in preventing full transitions into sleep, the two drugs...
Orexin receptor antagonists differ from standard sleep drugs by promoting sleep at doses that do not disrupt cognition. Sci Transl Med. 2013;5:179ra44. Article PubMed Google Scholar Miller GM, Verrico CD, Jassen A, Konar M, Yang H, Panas H, et al. Primate trace amine receptor 1 ...