VS-4718 (PND-1186) is a reversible and selective FAK inhibitor with IC50 of 1.5 nM. PND-1186 selectively promotes tumor cell apoptosis. Phase 1.
400 FAK Inhibitor VS-4718 Attenuates Breast Cancer Stem Cell Function and Inhibits Tumor Growth in Vivo - European Journal of Cancerdoi:10.1016/S0959-8049(12)72198-6Xu, Q.Kolev, V.N.Vidal, C.M.Shapiro, I.M.Ring, J.E.Padval, M.V....
Overexpression of ATP-binding cassette (ABC) transporters is one of the most important mechanisms responsible for multi-drug resistance (MDR). VS-4718, a tyrosine kinase inhibitor targeting focal adhesion kinase (FAK) with a potential anticancer effect, is currently evaluated in clinical trials. In...
备注卖完停产,不再备货 产品介绍 PND-1186是高活性FAK抑制剂,IC50为1.5 nM。 PND-1186 is a potent FAK inhibitor with IC50 of 1.5 nM. 产品属性 关联靶点(人) 名称和识别符 数据库链接 化学和物理性质 质检证书(COA) 相关文档 参考文献 溶液计算器...
Stephen T. KeirJohn M. MarisRichard B. LockHernan CarolMin KangC. Patrick ReynoldsJianrong WuWiley-Liss Inc.Initial testing of VS‐4718,a novel inhibitor of focal adhesion kinase (FAK),against pediatric tumor models by the pediatric preclinical testing program. Kurmasheva RT,Gorlick R,Kolb EA...