The kinase activity of VRK1 is inhibited by a direct interaction of its N-terminal kinase domain with SIRT2 in vitro. This interaction causes a loss of H4K16ac similarly to the effect of a novel VRK1 inhibitor (VRK-IN-1) or VRK1 depletion. The use of specific SIRT...
VRK1adenosine triphosphateATPVaccinia-related kinase 1 (VRK1), a serine/threonine mitotic kinase, is widely over-expressed in dividing cells and regarded as a cancer drug target primarily due to its function as an early response gene in cell proliferation. However, the mechanism of VRK1 ...
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Deficiency of vrk1 causes mild microcephaly in zebrafish.Impaired locomotor activity and decreased anxiety are noted invrk1/zebrafish.Reduced dopamine content observed in the brains ofvrk1/zebrafish.Vrk1/zebrafish show nuclear envelope defects and increased brain heterochromatin. 关键词: VRK1 Zebrafish ...
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答案(1)细节理解题。根据原文Look,I am in a blue and yellow jacket.(看,我穿着一件蓝黄相间的夹克。)可知是蓝黄相间的。故答案为:D。(2)细节理解题。根据原文Amy is in a green and blue jacket.She's Ms Black's daughter.(艾米穿着一件绿蓝相间的夹克。她是布莱克女士的...
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VRK1adenosine triphosphateATPVaccinia‐related kinase 1 (VRK1), a serine/threonine mitotic kinase, is widely over〆xpressed in dividing cells and regarded as a cancer drug target primarily due to its function as an early response gene in cell proliferation. However, the mechanism of VRK1 ...