Because of that, induction of DNA damage by radiation or chemotherapeutic drugs that directly cause DNA damage is a common mechanism of action of cancer treatments. However, these therapeutic ap- proaches frequently have a high toxicity and side effects leading to incomplete treatments. Therefore, ...
Because of that, induction of DNA damage by radiation or chemotherapeutic drugs that directly cause DNA damage is a common mechanism of action of cancer treatments. However, these therapeutic ap- proaches frequently have a high toxicity and side effects leading to incomplete treatments. Therefore, ...
Levine AJ (2017) The p53 protein plays a central role in the mechanism of action of epigenetic drugs that alter the methyla- tion of cytosine residues in DNA. Oncotarget 8(5):7228–7230. https://doi.org/10.18632/oncotarget.14805 83. Moll UM, Petrenko O (2003) ...
DNA damage was induced by ionizing radiation with 0.5, 1 or 3 Gy using a Gammacell 1000 Elite irradiator (Theratronics, Ottawa, Canada) with a 137Cs source, and exposure to different concentrations of Olaparib (PARP inhibitor, LC Laboratories; Woburn, MA, USA), or their combinations, as ...