【16】 Burden DA, Kingma PS, Froelich-Ammon SJ, et al.Topoisomerase II.etoposide interactions direct the ation of drug-induced enzyme-DNA cleavage compls[J].J Biol Chem, 1996, 271(46):29238-29244. 下载提示(请认真阅读) 1.请仔细阅读文档,确保文档完整性,对于不预览、不比对内容而直接下载带来...
the sequence specificity of drug-mediated topoisomerase II poisoning [J].Mol Phar macol,1998, 54(6):1036-1045. 【13】 Nabiev I, Chourpa I, Riou JF, et al.Molecular interactions of DNA-topoisomerase I and II inhibitor with DNA and topoisomerases and in ...
The diastereoisomeric impurities of the antitumordrug etoposide (Vp16)have been isolated by using phase solubiliy analysis, column chromatography and thin-layer chromatography.These two diastereoisomers of etoposide(Vp16)were examined by UV, IR, MS,1HNMR and specific optical rotation.The Ist isomer...
(VP16)resistantcelllineJAR/VP16ofhumanchoriocarcinoma,andtodetectthe biologicalcharacteristicsofthecell,andtoanalyzetheexpressionofitsmuhidrugresistance—andapoptosis-associatedgenes,soasto investigateacorrelationbetweenmuhidrugresistanceandapoptosis-associatedgenesexpression.Methods:Theresistantcelllinewas obtainedinvitro...
19,20 On the other hand, preliminary results obtained with VP 16 in advanced CMML were encouraging: Oscier et al,14 showed that this drug, at an initial oral dose of 100 mg daily for 3 days orally, lead to rapid reduction of WBC and resolution of serous effusions in CMML. VP16 at ...
In small cell lung cancer (SCLC) the DNA double-strand break (DSB) inducing agent etoposide (VP16) yields remissions in 70% of the patients when used in single drug regimens [4]. Nevertheless, in SCLC therapy drug resistance often evolves during treatment resulting in relapse of disease and...
Mutants of Chinese hamster ovary (CHO) cells independently selected for resistance to the anticancer drug 4′-demethylepipodophyllotoxin thenylidene-β-d-g... Radhey,S.,Gupta,... - 《Jnci J Natl Cancer Inst》 被引量: 9发表: 1984年 176 Combination chemotherapy with cisplatin and teniposide ...
BACKGROUND & OBJECTIVE:Expression of O6methylguanine-DNA methyltransferase (MGMT) has been related to drug resistance of glioma patients. This article is t... 张俊平,魏大年,李刚,... - 《中国神经肿瘤杂志》 被引量: 0发表: 2009年 依托泊苷联合洛铂或顺铂治疗广泛期小细胞肺癌的对照研究 目的观察洛铂...
Ad-PUMA sensitizes drug-resistant choriocarcinoma cells to chemotherapeutic agents. Gynecol. Oncol. 107:505-512(2007) JEG-3/VP16人绒癌细胞耐药株特点和简介 对VP16耐药,间歇用药。 JEG-3/VP16人绒癌细胞耐药株接受后处理 1) 收到细胞后,请检查是否漏液 ,如果漏液,请拍照片发给我们。 2) 请先在显微镜...
drug-resistant Ewing’s sarcoma. Key words:Ad—E1A Ewing’s sarcoma Gene Therapy VP.16 HER2/neu 4 硕士学位论文 中南大学 英文缩写词表 VP—16 Ad—ElA Ad—p—gal DMS0 EMEM FBS SP MEMvilamins NA G1u TUNEL Rr—PCR DAPI TDT PFU