The von Willebrand factor antigen (factor VIII-related antigen, VIIIR:Ag) multimer pattern has been analysed by SDS-agarose electrophoresis of plasmas from 116 patients (47 families) with von Willebrand's disease. In addition to previously recognized patterns, a subclassification was established ...
1) von Willebrand Factor (vWF) 温韦伯因子 1. Objective: To investigate the expression and role of vascular endothelial growthfactor (VEGF), von Willebrand Factor (vWF), very late antigen alfa-2 (VLA-2a) and tissue inhibitor of metalloproteinase-2 (TIMP-2) in the angiogenesis and invasion of...
The effect of ABO blood group on the diagnosis of von Willebrand disease In order to firmly establish a normal range for von Willebrand factor antigen (vWF:Ag), we determined plasma vWF:Ag concentrations in 1,117 volunteer blood... JC Gill,J Endres-Brooks,PJ Bauer,... - 《Blood》 被引...
von Willebrand collagen-binding activitybleeding timedesmopressin (DDAVPvon Willebrand factor concentratesThe quality and interpretation of intravascular ultrasound (... EB Diethrich,K Irshad,DB Reid - 《Seminars in Vascular Surgery》 被引量: 43发表: 2006年 ABO blood group and von Willebrand factor: ...
Diagnosis can be challenging; some individuals with low von Willebrand factor (VWF) levels may not actually have VWD (or any bleeding disorder), whereas others who have never had a bleeding challenge or never been tested have a significant bleeding risk from VWD that would benefit from ...
38 Therefore, we favor the interpretation that, under static conditions, differences in binding between rTyr2561-VWF and rPhe2561-VWF to GPIIb/IIIa will rather be negligible, speaking against a higher affinity of rTyr2561-VWF to GPIIb/IIIa. In addition, although not unexpected, we excluded a ...
Article: A novel Alu-mediated 61-kb deletion of the von Willebrand factor (VWF) gene whose breakpoints co-locate with putative matrix attachment re
BD, bleeding disorder; BMI, body mass index; N/A, not applicable; VWD, von Willebrand disease; VWF:Act, von Willebrand factor activity; VWF:Ag, von Willebrand factor antigen. a All pregnancies, including pregnancy losses. Other race/ethnicity: VWD: Jewish, Ashkenazi Jewish, Hungarian; Mucocuta...
Laboratory assessment of von Willebrand factor: altered interpretation of laboratory data, and altered diagnosis of von Willebrand's disease, as influenced by the use of different vWF assays and assay conditions. Clin Appl Thromb/Hemost. 1997;3:110 -118....
Trp-50 of the heavy and His-49 of the light chain, both situated adjacent to the patch, play ancillary roles in antigen binding. The crystal structure furthermore confirms the epitope location, which largely overlaps with the collagen binding site deduced from mutagenesis of the A3-domain (...