This apparent tendency for the GDF15/GFRAL-RET system to exhibit some degree of desensitization provides a plausible explanation for the effects of prepregnancy GDF15 exposure on the risk of NVP and HG developing in the face of the acute increase in circulating GDF15 which begins in early ...
There is a tendency for CINV to Table 2 Responses to treatment in the aprepitant group and the standard therapy group by cycle of cisplatin, and estimated probabilities of full responsea Cycle 1 (N=1038) 2 (N=589) 3 (N=448) 4 (N=312) 5 (N=212) 6 (N=167) Aprepitant regimen ...