Voltage-gated calcium channel antibodyLambert–Eaton myasthenic syndromeAutoimmune encephalitisAs testing for neuronal antibodies become more readily available, the spectrum of conditions potentially associated with these autoantibodies has been widening. Voltage-gated calcium channel......
Excitable cells — including neurons, muscle cells and cardiac myocytes — are unique in expressing high densities of voltage-gated sodium (NaV) channels. This molecular adaptation enables these cells to produce action potentials, and is essential to the
C1 to CA Antibodies to Voltage-Gated Ion Channels Antibodies to Ion Channels Antibodies to Calcium ChannelsAntibodies Alphabetical Index Anti-Calcium Channel (γ3 Subunit) (Voltage Gated Ca2+ Channel) antibody produced in rabbit ANTI-CALCIUM CHANNEL (GAMMA3 SUBUNIT) (VOLTAGE GATED CA2+ CHANNEL)Copyri...
ChemicalBook 致力于为化学行业用户提供ANTI-CALCIUM CHANNEL (BETA2 SUBUNIT) (VOLTAGE GATED CA2+ CHANNEL) RABBIT的性质、化学式、分子式、比重、密度,同时也包括ANTI-CALCIUM CHANNEL (BETA2 SUBUNIT) (VOLTAGE GATED CA2+ CHANNEL) RABBIT的沸点、熔点、MSDS、用途、作
Characterisation of anti voltage-gated calcium channel antibodies using a small cell lung carcinoma line derived from a patient with lambert-eaton myasthenic syndrome: I. Johnston, B. Lang, K. Leys and J. Newsom-Davis. Neurosciences Group, Institute of Molecular Medicine, John Radcliffe Hospital, ...
In certain disease processes, voltage-gated calcium channels on autonomic neurons can be targeted; for example antibodies to P/Q-type VGCCs in Lambert–Eaton myasthenic syndrome downregulate VGCCs, thereby inhibiting autonomic neuroeffector transmission. 展开 关键词: ACh, Acetylcholine ATP, Adenosine...
The circulating antibodies against α1A subunit protein, and to a lesser degree, β1B subunit protein of the N-type calcium channels, are found in LES patients (Lennon et al., 1995). Moreover, antibodies directed against the peptide corresponding to the unique acidic stretch in the IV S5-...
We have tested 29 patients with the Lambert-Eaton myasthenic syndrome (LEMS) for serum antibodies to voltage-gated calcium channels (VGCC) using an immunoprecipitation assay in which [125]-omega-conotoxin GVIA is used to label calcium ch... M Motomura,I Johnston,B Lang,... - 《Neuromuscula...
[15]. In the presence of Nav channels, this might result in a larger persistent sodium current, leading to downstream sodium gradient cascades and activating various signaling pathways and sodium-associated transmembrane mechanisms, such as Na + /H + exchangers [45] and sodium/calcium ...
Voltage-gated calcium channels (VGCC) have a key role in phy- siology, driving neuronal excitability and allowing influx of second messenger Ca2+ ions in response to membrane depolarization31–33. VGCC subtype Cav2.3 is formed by the ion-conducting α1E subunit (encoded by CACNA1E) in ...