On the fate of skeletal myoblasts in a cardiac environment: down-regulation of voltage-gated ion channels Wehaveanalysedthevoltage-gatedionchannelsandfusioncompetenceofskeletalmusclemyoblastslabelledwithgreenfluorescentprotein(GFP)andthemembranedyePKHtransplant... H.,C.,Ott,... - 《Journal of Physiology》...
Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, ... Antibodies that immunoprecipitate (125)I-alpha-dendrotoxin-labelled voltage-gated potassium channels extracted from mammalian brain tissue have been...
A survey of autoantibodies to (CgTx)-labelled voltage gated calcium channels (VGCCs) in patients with small cell lung carcinoma (SCLC)doi:10.1016/0896-8411(91)90151-2Elrington, GJohnston, ILeys, KLang, BNewson-Davis, JJournal of Autoimmunity...
Voltage-gated sodium channels (NaV) are responsible for the rapid depolarization of many excitable cells. They readily inactivate, a process where currents diminish after milliseconds of channel opening. They are also targets for a multitude of disease-causing mutations, many of which have been shown...
Voltage-gated calcium channels (VGCCs) are important protein-complexes found on excitable cells, including neurons, which mediates calcium entry (Yamakage and Namiki, 2002; Dolphin, 2006). VGCCs function as an assembly of five different channel subunits (α1, α2, β, γ, δ), with the α...
In voltage-gated channels, the position of the VSD is directly coupled to the open- or closed-state probability of the channel through the S4–S5 linker, whereas, in the SLC9C1 transporter, the VSD is required only to remove an inhibition so that the transporter can then cycle through its...
Measurement of this emitted light during membrane depolarization reveals changes in the emission level as the environment of the labelled residue changes. This allows for the correlation of channel gating events with movement of specific protein moieties, at nanosecond time resolution. Since the ...
In this paper, we show that mutation of acidic amino acid residues of the S2 and S3 segments in domain II alter sodium channel gating; this suggests that the S2, S3 and S4 segments in domain II may constitute a voltage-sensing structure for voltage-gated sodium channels, as has been shown...
To understand the molecular basis underlying this mode of action, we used nuclear magnetic resonance to delineate the atomic details of the interaction between the VSD of the voltage-gated potassium channel KvAP and the spider-venom peptide VSTx1. Our data reveal that the toxin interacts with ...
The cytoplasmic domains of G-protein-coupled inward rectifier K+ (GIRK) channel docks other regulatory elements such as G proteins (Gβγ) to the channel (Roosild 2004, adapted with permission from Elsevier Inc.). Table 3. Voltage-gated potassium channels and their blockers and activators ...