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Issue DateOctober 2024 DOIhttps://doi.org/10.1038/s41587-023-02078-y Share this article Anyone you share the following link with will be able to read this content:Get shareable link Provided by the Springer Nature SharedIt content-sharing initiative Subjects Genetic engineering Protein delivery ...
With functionalized loading matrices, nanometer-sized drug carriers can cross physiological barriers, effectively deliver therapeutics to pathological foci and release their cargo ‘on-demand’ by photo-/chemo-/thermo-triggering.1On the one hand, functionalization prevents the aggregation and degradation of...
J Control Release, 143 (2010), pp. 311-317 View PDFView articleView in ScopusGoogle Scholar 145 H Hatakeyama, H Akita, E Ito, Y Hayashi, M Oishi, Y Nagasaki, et al. Systemic delivery of siRNA to tumors using a lipid nanoparticle containing a tumor-specific cleavable PEG-lipid Biomaterial...
the Vivo Y200 seems like just another smartphone. The Vivo Y200 has nothing unique to offer that other smartphones don’t already have in the same price bracket. Other smartphones such as the Vivo iQOO Z7 Pro offer far better specs in almost every way at a similar price point. However...
To date, VRS-317 has been administered to rats, pigs, and monkeys as single doses and to rats and monkeys as repeat doses up to 25 mg/kg (63 nmol/kg). No observable clinical signs or symptoms have been noted in these studies. In the juvenile cynomolgus monkey study, no test article...
To date, direct evidence for any of these mechanisms in vivo is limited [35,80], primarily due to the previous inability to track the movement of aggregated alpha-synuclein following PFF injection. In support of the neuronal uptake and transport model, data from cell culture experiments show th...
gd, underhill dm. interactions between commensal fungi and the c-type lectin receptor dectin-1 influence colitis. science. 2012;336(6086):1314–7. barrett na, rahman om, fernandez jm, parsons mw, xing w, austen kf, kanaoka y. dectin-2 mediates th2 immunity through the generation of ...
To assess total LDH in cells, Triton X-100 was added to vehicle (control) wells to release intracellular LDH. LDH assay reagent was added to lysates or supernatants and incubated for up to 30 min at room temperature in dark, the reaction was stopped, and the absorbance was measured at ...