We used these v1 ZF-DdCBEs as the starting point for development and optimization. We hypothesized that ZF-DdCBE editing outcomes might be limited if the linker between the ZF array and the split DddA deaminase constrained access of reassembled DddA to the target nucleotide(s). We replaced ...
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Recurrent driver mutations inFLT3occur in approximately one-third of patients with de novo AML as internal tandem duplications (ITD) in the juxtamembrane domain or point mutations in the activation loop of the tyrosine kinase domain (Fig.1a), which are screened for in routine diagnostics of AML32...
Fast forward today, vivo has finally announced not one, not two, but three new smartphones, pandemic notwithstanding. The V20 series lineup goes like this: the V20 SE, V20, and this one, the V20 Pro. If you’ve been fond of vivo’s V-lineup, they always skip models in odd numb...