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A zebrafish functional genomics model to investigate the role of human A20 variants in vivoLOGPERCHGENOMESAUTOIMMUNE diseasesMISSENSE mutationCANCER invasivenessGermline loss-of-function variation in TNFAIP3, encoding A20, has been implicated in a wide variety of autoinflammatory and autoimmune conditions, ...
and their application as antibiotics does not justify a high price. In summary, chemical synthesis could be a faster approach to tackle pharmaceutical production, but process scale-up is so far not economically feasible and hence, biological production seems to be the only realistic alternative. Thi...
Chronic lung diseases are devastating diseases that are increasing in prevalence. Most have no cure and lung transplantation remains the only available therapeutic option. However, the number of suitable donor lungs is inadequate to meet current clinical
in a Chinese hamster ovary model [17], which was later confirmed to be caused by a cell surface p-glycoprotein [18]. However, transport by ABCB1 or other ABC transporters has not been fully characterised. In the current study the transport of Act D by a number of ABC transporters was ...
We have used zebrafish to generate an in vivo model with increased astroglial DJ-1 expression. Regulatory elements from the zebrafish glial fibrillary acidic protein (GFAP) gene [22] were used to drive the astrocyte specific over-expression of DJ-1 in the transgenic line. In this study we ...