A recently published case series describes eight patients on chronic warfarin therapy whose widely fluctuating INRs stabilized after adding low-dose (100 mcg) oral vitamin K to their daily regimen. 1 The number of INRs in the therapeutic range increased and the standardEM Stansbury...
It has been reported that treatment with a pharmacological dose (45 mg/d) of menaquinone-4 (MK-4) prevents bone loss in postmenopausal women. However, it is not known whether supplementation with low dose MK-4 has beneficial effects on bone metabolism in healthy women. The aim of this stud...
Table 3. Effects of acenocoumarol and menaquinone-7 (MK-7) supplementation on markers of coagulation and vitamin K status WeekMK-7 daily dose (μg)Plasma or serum concentrations or parameter values Acenocoumarol (μg L–1)INR -Thrombin generationGla-proteins ETP (%)Peak (%)Lag time (mi...
Articles Vitamin D supplementation of breastfed infants: a randomized dose–response trial Ekhard E. Ziegler1, Steven E. Nelson1 and Janice M. Jeter1 Background: Breastfed infants require supplementation with vitamin D (vD), but little is known about the necessary dose. This...
In a separate recommendation statement,18 the USPSTF found that vitamin D supplementation does not reduce the number of falls or the number of persons who experience a fall. A single study suggested that an annual high dose of vitamin D (500 000 IU) may even be associated with a greater...
Effect of Vitamin D Supplementation on Outcomes View LargeDownload Nelson-Aalen cumulative hazard curves are shown for (A) relapse or death and (B) total deaths. In panel C, the cumulative incidence of relapse is compared between the vitamin D and placebo groups by considering patient deaths ...
The mechanism by which high dose vitamin D supplementation increased colitis susceptibility remains unclear, but we did observe that vitamin D had a potent effect on the microbial composition of faeces from plain-water treated, control mice. Interestingly, the microbial composition of faeces from D++...
The harm of vitamin E supplementation was restricted to participants with dietary vitamin C intake above the median. Conclusion Vitamin E supplementation may cause harmful effects on health in certain groups of male smokers. The dose of vitamin E used in the ATBC Study, 50 mg/day, is ...
This randomized trial compares the effects of vitamin D, omega-3s, and a strength-training exercise program alone or in combination vs no supplementation
This randomized clinical trial examines whether monthly high-dose vitamin D supplementation prevents cardiovascular disease in the general population.