Pharmacologic doses of vitamin E not recommended for prevention or treatment of retinopathy of prematurity† [off-label], bronchopulmonary dysplasia†, or intraventricular hemorrhage†.108Cancer Risk ReductionUse of vitamin E alone in conjunction with selenium does not decrease the risk of prostate...
Pharmacologic prophylaxis of postoperative atrial fibrillation in patients undergoing cardiac surgery: beyond beta-blockers. Pharmacotherapy. 2010;30(7):749 (274e–318e). Article PubMed Google Scholar Ambrosetti M, Tramarin R, Griffo R, De Feo S, Fattirolli F, Vestri A, et al. Late ...
Proc Natl Acad Sci USA 104: 8749 – 8754 Chen Q, Espey MG, Krishna MC, Mitchell JB, Corpe CP, Buettner GR, Shacter E, Levine M (2005) Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues. Proc Natl Acad ...
et al. Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo. Proceedings of the National Academy of Sciences 104, 8749–8754 (2007). 25. Nishikimi, M., Fukuyama, R., Minoshima, S., Shimizu, N. & Yagi, K. ...
Treatment of hypovitaminosis D with pharmacologic doses of cholecalciferol, oral vs intramuscular; an open labeled RCT. Clin Endocrinol (Oxf). 2013;78(2):210–6. doi:10.1111/j.1365-2265. 2012.04518.x. 34. Bhargava P, Steele SU, Waubant E, Revirajan NR, Marcus J, Dembele M, et al....
Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice. Proc. Natl. Acad. Sci. USA 2008, 105, 11105–11109. [Google Scholar] [CrossRef] [Green Version] Doskey, C.M.; Buranasudja, V.; Wagner, B.A.; Wilkes, J.G.; Du, J...
Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells. Nutr. Cancer 2011, 63, 1133–1142. [Google Scholar] [CrossRef] [PubMed] [Green Version] Hardaway, C.; Badisa, R.; Soliman, K. Effect of ascorbic acid...
(a) continued on vitD-free diet or (b) received an oral dose of 100,000 IU/Kg of vitD plus standard diet for three weeks. Hemodynamics, pulmonary vascular remodeling, pulmonary arterial contractility, and K+currents were analyzed.Results:Recovering optimal levels of vitD improved endothelial ...
Vitamin D and evolution: Pharmacologic implications. Biochem. Pharmacol. 2020, 173, 113595. [CrossRef] 3. Holick, M.F. Vitamin D: Evolutionary, physiological and health perspectives. Curr. Drug Targets 2011, 12, 4–18. [CrossRef] [PubMed] 4. Wacker, M.; Holick, M.F. Sunlight and ...
Further studies are required to study this issue in more detail and to differentiate between physiologic (at low concentrations) and pharmacologic (at high concentrations) actions of the LCMs. To sum up, the LCMs could be regarded as the metabolically activated forms of vitamin E. This is in ...