Ekelund H, Finnstrom O, Gunnarskog J, et al. Administration of vitamin K to newborn infants and childhood cancer. BMJ 1993;307:89-91.Ekelund H, Finnstrom0,GunnarskogJ, KallenB, LarssonY. Adminis- tration of vitamin K to newborn infants and childhood cancer. BMJ 1993; 307: 89-91....
Hyperbilirubinemia has been observed in the newborn following administration of phytonadione. This has occurred rarely and primarily with doses above those recommended. (See PRECAUTIONS, Pediatric Use.) Overdosage The intravenous LD50 of Vitamin K1 Injection (Phytonadione Injectable Emulsion, USP) in ...
In newborn infants, the absence of intestinal bacteria, low levels of vitamin K in the mother’s milk, or the absence of body stores of vitamin K may result in bleeding, which can be prevented by the administration of vitamin K to the infant shortly after birth. (See table of the ...
Oral or parenteral administration of vitamin K is the accepted practice for prevention of early vitamin K deficiency bleeding (VKDB) in the newborn. However, vitamin K prophylaxis in the newborn continues to be a worldwide health concern, particularly in breastfed infants. This paper reviews the...
We looked at existing recommendations and supporting evidence on the effectiveness of vitamin K given after birth in preventing the haemorrhagic disease of the newborn (HDN).#We conducted a literature search up to the 10th of December 2019 by using key terms and manual search in selected sources...
Plasma levels of vitamin K (VK) and VK dependent proteins ( factor E, factor VH, factor X, protein C and osteocalcin)were determined before and after VK administration to 22 newborn infants. Vitamin K2syrup ( 2 mg/kg of body weight ) was orally administered to 9 healthy premature, 11 ...
Objectives: To describe rates of newborn vitamin K prophylaxis uptake according to method of administration (intramuscular [IM], oral, refused) and identify predictors for the choice of oral administration and for refusal of vitamin K prophylaxis. Methods: A retrospective cohort study examined the re...
Vitamin K was introduced because babies who developed haemorrhagic disease of the newborn (HDN) invariabbly died. I have read that in Australia, when oral vit K was introduced the no. of babies who developed bleeding problems increased so the policy was changed back to the injection. The inje...
Vitamin K was not discovered until 1929 when Dam 2 serendipitously observed bleeding in chickens fed a fat-free diet. Soon afterward, Brinkhous et al.3 documented low prothrombin levels in normal newborn infants. Others demonstrated that these low levels could be elevated by the administration of...
Administration of vitamin K to newborn infants and childhood cancer. Objectives—To investigate whether childhood cancer is associated with intramuscular administration of vitamin K to newborn infants. Design—Routines for a... H Ekelund,O Finnstrom,J Gunnarskog,... - Bmj 被引量: 190发表: 1993...