Is administration of vitamin K to the newborn of clinical value? JAMA 1942;118:697-702.Sanford, H. N., Shmigelsky, I., and Chapin, J. M. (1942). Is adminis- tration of vitamin K to the newborn of clinical value? J. Amer. med. Ass., 118, 697....
Treatment of Hemorrhagic Disease of the Newborn Empiric administration of vitamin K1 should not replace proper laboratory evaluation of the coagulation mechanism. A prompt response (shortening of the prothrombin time in 2 to 4 hours) following administration of vitamin K1 is usually diagnostic of hem...
Discusses issues on vitamin K deficiency among newborn infant. Complications of the deficiency; Occurrence of hemorrhagic disease of the newborn; Results of a study on the association between childhood cancer and pethidine and vitamin K administration in Great Britain; Recommendations of the American ...
We looked at existing recommendations and supporting evidence on the effectiveness of vitamin K given after birth in preventing the haemorrhagic disease of the newborn (HDN).#We conducted a literature search up to the 10th of December 2019 by using key terms and manual search in selected sources...
Plasma levels of vitamin K (VK) and VK dependent proteins ( factor E, factor VH, factor X, protein C and osteocalcin)were determined before and after VK administration to 22 newborn infants. Vitamin K2syrup ( 2 mg/kg of body weight ) was orally administered to 9 healthy premature, 11 ...
Vitamin K was introduced because babies who developed haemorrhagic disease of the newborn (HDN) invariabbly died. I have read that in Australia, when oral vit K was introduced the no. of babies who developed bleeding problems increased so the policy was changed back to the injection. The inje...
Keith DA, Gallop PM (1979) Phenytoin, skeletal defects and vitamin K in the newborn. Med Hypotheses 5: 1347–1351 PubMed CAS Google Scholar Keith DA, Gundberg CM, Gallop PM (1980) Phenytoin therapy and hemorrhagic disease. J Pediatr 97: 501 PubMed CAS Google Scholar Kelly DA, Summerf...
In newborn infants, the absence of intestinal bacteria, low levels of vitamin K in the mother’s milk, or the absence of body stores of vitamin K may result in bleeding, which can be prevented by the administration of vitamin K to the infant shortly after birth. (See table of the ...
What is the history of giving Vitamin K to newborns? In 1894, a Boston physician named Dr. Townsend described 50 cases of bleeding in newborns. He called these cases “Haemorrhagic Disease of the Newborn (HDN).” Dr. Townsend was the first person to figure out that there was a connection...
Vitamin K was not discovered until 1929 when Dam 2 serendipitously observed bleeding in chickens fed a fat-free diet. Soon afterward, Brinkhous et al.3 documented low prothrombin levels in normal newborn infants. Others demonstrated that these low levels could be elevated by the administration of...