Vitamin K3 exhibited the lowest affinity with VKORC1 because of the absence of a hydrophobic tail, preventing structural stabilization by the enzyme. Enzymatic activity towards vitamins K1, MK4, MK7, and K3 was also evaluated by in vitro assays, validating our in silico predictions: VKORC1 ...
Munger, K.L.; Levin, L.I.; Hollis, B.W.; Howard, N.S.; Ascherio, A. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA 2006, 296, 2832–2838. [CrossRef] [PubMed] 9. Poole, K.E.; Loveridge, N.; Barker, P.J.; Halsall, D.J.; Rose, C.; Reeve, J...
Keywords: vitamin D receptor; breast cancer; KCa1.1; K+ channel; transcription; protein degradation 1. Introduction Breast cancer is the most common cancer in women, affecting more than two million women worldwide. The multifunctional pro-hormone vitamin D (VD) and its metabolites activate ...