In the prophylaxis and treatment of hemorrhagic disease of the newborn, phytonadione has demonstrated a greater margin of safety than that of the water-soluble vitamin K analogues. Indications and Usage for Vitamin K1 Vitamin K1 Injection (Phytonadione Injectable Emulsion, USP) is indicated in the ...
Objectives: This study was conducted to investigate the impacts of maternal B complex vitamin injection on performance and plasma parameters in goats and their offspring, as well as the faeces status of newborn kids. Methods: In this research, the pregnant goats (3 years old) were randomly ...
(IM) vitamin K prophylaxis in every newborn since 1961 (Figure 1). That is more than 50 years of routine use in every newborn nursery, adding up to nearly 200 million doses in the United States alone. And for newborns, vitamin K delivered intramuscularly has shown almost no known ...
Although low vitamin K levels have not been found to affect the developing fetus in a functionally deleterious way, it is clear that the newborn, and especially the solely breast-fed infant, is at a higher risk of functional deficiency than older infants and adults. In a minority of cases,...
To determine the role of TNF, newborn C57BL/6J mice were given intraperitoneal injections of TNF (2.5 μg/gbw) or saline. Pups were sacrificed eight hours after injection, and the ileum was isolated and harvested for histopathologic evalu- ation as above. Infants with NEC have significantly ...
The enhanced biological activity of this new metabolite was evident before its structure could be determined [54–56]. Fraser and Kodicek [56] demonstrated that nephrectomy abolished production of the new metabolite, and this active vitamin D compound was synthesized by kidney mitochondria. In 1971...
also recommended to prevent and treat hemorrhagic disease of the newborn. Use is typically recommended by mouth or injection under the skin.Use by injection into a vein or muscle is recommended only when other routes are not possible. When given by injection benefits are seen within two hours....
Vitamin K administration via intramuscular injection is highly efficient in preventing VKDB, but the administration route is sometimes considered an issue, especially due to the potential incidents of muscle damage or pain caused to the neonates [4]. Vitamin K has been used for VKDB prophylaxis ...
Retinol status of newborn infants is associated with congenital diaphragmatic hernia. Pediatrics 2010, 126, 712–720. 250. Pasutto, F.; Sticht, H.; Hammersen, G.; Gillessen-Kaesbach, G.; Fitzpatrick, D.R.; Nurnberg, G.; Brasch, F.; Schirmer-Zimmermann, H.; Tolmie, J.L.; ...
In most Western countries, a single prophylactic intramuscular injection of vitamin K is administered at birth and greatly reduces the rate of the hemorrhagic disease of the newborn [6]. In vertebrates, the only well-described cellular function of vitamin K is to support γ-glutamyl carboxylation...