Infants are at a higher risk of vitamin K deficiency as vitamin K doesn't pass through the placenta easily and breast milk is a poor source of the nutrient, perOregon State University. Because low vitamin K levels increase the risk of excessive bleeding, newborns are given a vitamin K suppl...
There are no randomized trials comparing the oral and intramuscular route of administration of prophylactic vitamin K in newborns. From older trials and surveillance data, it seems that there is no significant difference between the intramuscular and the oral regimens for preventing classical and late ...
Vitamin K is most commonly used for blood clotting problems. For example, vitamin K is used to reverse the effects of "blood thinning" medications when too much is given. It is also used to prevent clotting problems in newborns who don't have enough vitamin K. Vitamin K is also given to...
Benzyl alcohol as a preservative has been associated with toxicity in newborns. Therefore, all of the above diluents should be preservative-free (See WARNINGS). Other diluents should not be used. When dilutions are indicated, administration should be started immediately after mixture with the ...
What is the history of giving Vitamin K to newborns? In 1894, a Boston physician named Dr. Townsend described 50 cases of bleeding in newborns. He called these cases “Haemorrhagic Disease of the Newborn (HDN).” Dr. Townsend was the first person to figure out that there was a connection...
Vitamin K prophylaxis in newborns 来自 EBSCO 喜欢 0 阅读量: 57 作者: S Jullien 摘要: We looked at existing recommendations and supporting evidence on the effectiveness of vitamin K given after birth in preventing the haemorrhagic disease of the newborn (HDN).#We conducted a literature search ...
Newborns have a higher chance of having vitamin K deficiency because of low transfer from the placenta and breast milk. Vitamin K is available in multivitamins, single-nutrient supplements, injections, and drops. You can also get it through various foods. Although the side effects of vitamin K ...
Another probable etiologic factor is the precarious hepatic stores of vitamin K in newborns because of poor placental transfer of phylloquinone and the lack of neonatal stores of bacterial MKs, which only build up slowly after bacterial colonization of the intestine. Some infants who develop late ...
No toxicity or side effects were seen. Vitamin K deficiency is a known cause of bleeding disorders, particularly fatal and handicapping intracranial hemorrhage in newborns, in developing countries where injections cannot be given by midwives. These inexpensive oral pediatric drops may provide a ...
Sign in to download full-size image Figure 1. The vitamin K-dependent, γ-glutamyl carboxylase. The available data support an interaction of O2 with vitamin KH2, the reduced (hydronaphthoquinone) form of vitamin K, to form an oxygenated intermediate which is sufficiently basic to abstract the ...