GENERIC NAME: VITAMIN K - ORAL BRAND NAME(S): Mephyton Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage USES: Vitamin K is used to treat and prevent low levels of certain substances (blood clotting factors) that...
In addition, menadione was compared with cholesterol and ergosterol for similarity in mechanism of drug modulatory action. Antibiotic-modifying activity and antibacterial effect were determined by the broth microdilution assay. Menadione, cholesterol and ergosterol showed modulatory activity at clinically ...
Vitamin K, any of several fat-soluble naphthoquinone compounds. Vitamin K (from the Danish word koagulation) is required for the synthesis of several blood clotting factors, including prothrombin and factors VII, IX, and X. A form of vitamin K known as p
The naphthoquinones, vitamin K3 and its structural analogue plumbagin, are substrates of the multidrug resistance linked ATP binding cassette drug transpor... Nandigama, K.Ambudkar, S. V.Molecular Cancer TherapeuticsThe naphthoquinones, vitamin K3 and its structural analogue plumbagin, are substrates...
other drug-induced hypoprothrombinemia where it is definitely shown that the result is due to interference with vitamin K metabolism, e.g., salicylates. Contraindications Hypersensitivity to any component of this medication. Warnings Benzyl alcohol as a preservative in Bacteriostatic Sodium Chloride Injec...
The antitumor action of vitamin K has been investigated since 19474. In rats, VK3 acts against adriamycin-resistant leukemia cells5. VK3, a radiosensitizing agent, extends the survival time of patients with bronchial carcinoma, and VK2 induces growth inhibition via cell cycle arrest6,7. VK2 ex...
(K); this vitamin K is then further reduced to vitamin K hydroquinone (KH2) by a yet-unknown enzyme3,4. VKOR is the target of the popular vitamin K antagonist (VKA) drug warfarin, which is widely used to treat thrombosis5. Warfarin inhibits the activity of VKOR, thereby preventing ...
In particular, we pay special attention to new human bone cell models, since these have the greatest relevance to osteoporosis research and drug discovery. These new models include (1) the use of peripheral blood mononuclear cells as progenitors of osteoclasts and primary cultures of mesenchymal ...
Brown AJ, Slatopolsky E. Drug insight: vitamin D analogs in the treatment of secondary hyperparathyroidism in patients with chronic kidney disease. Nat Clin Pract Endocrinol Metab. 2007;3(2):134–44. ArticlePubMedCASGoogle Scholar Slatopolsky E, Finch J, Ritter C, et al. A new analog of...
Drug interactions also occur through affecting the pharmacodynamics of warfarin. Second- and third-generationcephalosporinsinhibit the cyclic interconversion of vitamin K, which can increase the anticoagulant effect of warfarin.49,50Thyroxineincreases the metabolism of coagulation factors, andsalicylatedoses gr...