M. (1942). Is adminis- tration of vitamin K to the newborn of clinical value? J. Amer. med. Ass., 118, 697.Sanford, H. N., Shmigelsky, I., and Chapin, J. M. Is Administration of Vitamin K to the New- born of Clinical Value? J.A.M.A., 118:697 (Feb. 28), 1942....
A prompt response (shortening of the prothrombin time in 2 to 4 hours) following administration of vitamin K1 is usually diagnostic of hemorrhagic disease of the newborn, and failure to respond indicates another diagnosis or coagulation disorder. Vitamin K1 Injection 1 mg should be given either ...
We looked at existing recommendations and supporting evidence on the effectiveness of vitamin K given after birth in preventing the haemorrhagic disease of the newborn (HDN).#We conducted a literature search up to the 10th of December 2019 by using key terms and manual search in selected sources...
Discusses issues on vitamin K deficiency among newborn infant. Complications of the deficiency; Occurrence of hemorrhagic disease of the newborn; Results of a study on the association between childhood cancer and pethidine and vitamin K administration in Great Britain; Recommendations of the American ...
In newborn infants, the absence of intestinal bacteria, low levels of vitamin K in the mother’s milk, or the absence of body stores of vitamin K may result in bleeding, which can be prevented by the administration of vitamin K to the infant shortly after birth. (See table of the ...
487 children without cancer. The researchers found that 39% of children with cancer had received the injectable Vitamin K, while 42% of children without cancer had received the Vitamin K. The researchers stated that “there is no convincing evidence that neonatal Vitamin K administration influences...
4. L. Parker et al., "Neonatal vitamin K administration and childhood cancer in the north of England: retrospective case-control study," BMJ (England) 316, no. 7126 (Jan 1998): 189-93. 5. S.J. Passmore et al., "Case-control studies of relation between childhood cancer and neonatal ...
Vitamin K was introduced because babies who developed haemorrhagic disease of the newborn (HDN) invariabbly died. I have read that in Australia, when oral vit K was introduced the no. of babies who developed bleeding problems increased so the policy was changed back to the injection. The inje...
Plasma levels of vitamin K (VK) and VK dependent proteins ( factor E, factor VH, factor X, protein C and osteocalcin)were determined before and after VK administration to 22 newborn infants. Vitamin K2syrup ( 2 mg/kg of body weight ) was orally administered to 9 healthy premature, 11 ...
Vitamin K was not discovered until 1929 when Dam 2 serendipitously observed bleeding in chickens fed a fat-free diet. Soon afterward, Brinkhous et al.3 documented low prothrombin levels in normal newborn infants. Others demonstrated that these low levels could be elevated by the administration of...