During vitamin load, the kidney accumulates large amounts of free vitamin B12, suggesting a possible storage function. In addition, vitamin B12 is metabolized in the kidney, suggesting a role in vitamin homeostasis. The folate receptor is important for the conservation of folate, mediating ...
Vitamin D3-25-hydroxylase in the liver and both 25-hydroxyvitamin D3-1-hydroxylase and 25-hydroxyvitamin D3-24 hydroxylase (1-OHase and 24-OHase) in the kidney were detectable in mole rats. As expected for vitamin D-deficient mammals, the 1-OHase activity predominated over the 24-OHase...
When taken orally, Dhingra says it’s fairly difficult to consume a significantly excessive amount of vitamin D, but he says that the fat-soluble vitamin can cause excess calcium buildup with nausea, vomiting, mental changes, increased urination, and kidney failure. "This is only ever in the ...
However, the abundance of VDR is relatively low compared to classic VDR organs such as the gut and kidney. Within the brain, the hypothalamus had the greatest abundance. In organs of high VDR abundance anywhere between 3 and 5 isoforms exist whereas the brain contains the single isoform. A ...
Vitamin D Ameliorates Podocyte Injury by Enhancing Autophagy Activity in Diabetic Kidney Disease VITAMIN DIntroduction: Restoration of podocyte autophagy is considered as a feasible strategy for the treatment of diabetic kidney disease (DKD). This study... Zhang, Xiaoyi,Zhang, Li,Wen, Yingzhen,......
is refractory to reprogramming in our mouse model3; however, we did observe a significant depletion of vitamin B12from the proximal tubules during reprogramming (Extended Data Fig.3b). The kidney is the primary site of B12concentration and storage in rodents, from where it is released for use ...
Very high vitamin D levels in the blood exceeding 375 nmol/L or 150 ng/mL are toxic, potentially causing side effects such as loss of appetite, nausea, vomiting, muscle weakness, confusion, dehydration, excessive thirst, and kidney stones.[7] Extremely high blood levels of vitamin D can eve...
Vitamin D; Vitamin D deficiency; chronic kidney disease; proteinuria1. Introduction Vitamin D (VD) is a pro-hormone essential for life in higher animals. It is present in few types of foods and is produced endogenously in the skin by a photochemical reaction [1]. There are two major forms...
Using primary cultures of neurons, astrocytes, microglia and oligodendrocytes (encompassing all major brain cell types), this group showed a broad distribution across all cell types but at a lower level than the kidney and liver. Strikingly, however, the addition of 1,25(OH)2D3 induced a ...
disease.Vitamin D has an inactive form and an active form that your body can use. Your kidneys and liver have enzymes that convert the inactive form into the active form. Kidney and liver diseases reduce the amount of these enzymes your body makes, which can increase your risk for vitamin ...