It also contributes to the secretion of sodium by the kidneys, reducing blood pressure. Many studies suggest that gamma-tocopherol can significantly reduce cardiovascular risk. It is also a very promising weapon against prostate cancer (5). Does vitamin E protect against prostate cancer? Different ...
Absorption is incomplete following administration of large doses and in patients with fat malabsorption, low protein intake, or hepatic or pancreatic disease.DistributionExtentStored mainly in the liver as retinyl palmitate and small amounts of retinol and retinal. Also stored in the kidneys, lungs,...
“Vitamin E” is the generic term for a group of lipid-soluble tocol and tocotrienol derivatives possessing varying degrees of vitamin activity, the most active of these compounds being ±-tocopherol. The tocopherols and tocotrienols are produced in green plants. The tocopherols are stored in highes...
Klotho is an anti-aging protein that is mostly secreted by the kidneys, the brain, and the thyroid. It plays a significant role in regulating kidney function and vascular health. Klotho gene is named after “the Spinner” (Clotho from Greek mythology), the goddess who spins the thread of ...
This study was to investigate if Vit.E regresses the HC - induced OS, and the regression is associated with an increase in the antioxidant reserve (AR). The studies were carried out in four groups of rabbits. The kidneys were removed under anesthesia. OS and AR in the renal tissue were ...
TheTNSALPgene, located on chromosome 1p36.12, encodes a tissue non-specific alkaline phosphatase enzyme, which is widely distributed in the liver, bones, kidneys, and developing teeth. Mutations in theTNSALPgene can result in either a complete loss or only 40% of normal alkaline phosphatase acti...
Epilepsy is a chronic disorder of the nervous system caused by abnormal discharges from brain cells. Structural, infectious, metabolic, immunologic, and unknown causes can contribute to the development of seizures. In recent years, there has been increas
ultraviolet B rays of the sun. Vitamin D binding protein transports D3to the liver, where it is hydroxylated to the inactive 25(OH)D form (calcidiol). In the kidneys, it is further hydroxylated by the enzyme 1-alpha-hydroxylase to active 1,25-dihydroxyvitamin D (calcitriol).(Kulie 2009...
In the context of disease, particularly chronic kidney disease, it is crucial to understand the interplay between vitamin D, the kidneys, and parathyroid hormone (PTH) which constitutes an endocrine loop instrumental in calcium homeostasis. Vitamin D, primarily in the form of calcitriol (1α,25-...
Furthermore, many studies focused on nephropathies reported that active vitamin D protects the kidneys through its anti-inflammatory and antifibrotic effects. Calcitriol has proven to have inhibitory effects on renal interstitial myofibroblasts, thus decelerating the progression to renal interstitial fibrosis...