Reports on research by doctors at the Schneider Children's Hospital, Albert Einstein College of Medicine of the results of vitamin E therapy on a condition called focal segmental glomerulosclerosis. Study conducted on rats; Findings revealed lowered...
“Vitamin E” is the generic term for a group of lipid-soluble tocol and tocotrienol derivatives possessing varying degrees of vitamin activity, the most active of these compounds being ±-tocopherol. The tocopherols and tocotrienols are produced in green plants. The tocopherols are stored in highes...
TNSALP gene mutations and epilepsy The TNSALP gene, located on chromosome 1p36.12, encodes a tissue non-specific alkaline phosphatase enzyme, which is widely distributed in the liver, bones, kidneys, and developing teeth. Mutations in the TNSALP gene can result in either a complete loss or onl...
Vitamin E was shown to prevent cancer and DNA damage in laboratory rat kidneys subjected to iron-mediated peroxidation [CANCER RESEARCH; Zhang, D; 57:2410-2414 (1997)] and may be of value in prevention of colon cancer by the use of supplements [CANCER EPIDEMIOLOGY, BIOMARKERS & PREVENTION; ...
ultraviolet B rays of the sun. Vitamin D binding protein transports D3to the liver, where it is hydroxylated to the inactive 25(OH)D form (calcidiol). In the kidneys, it is further hydroxylated by the enzyme 1-alpha-hydroxylase to active 1,25-dihydroxyvitamin D (calcitriol).(Kulie 2009...
It also contributes to the secretion of sodium by the kidneys, reducing blood pressure. Many studies suggest that gamma-tocopherol can significantly reduce cardiovascular risk. It is also a very promising weapon against prostate cancer (5). Does vitamin E protect against prostate cancer? Different ...
(calcidiol). It is then further hydroxylated in the kidneys to produce 1,25-dihydroxyvitamin D (calcitriol), the active form of the vitamin. Calcitriol functions as a hormone, regulating calcium and phosphate metabolism to maintain healthy bones and has roles in immune system modulation and other...
These animals also displayed smooth muscle cell hyperplasia in the small arteries and arterioles of the kidneys. Dietary vitamin E and C supplementation in fructose-treated WKY rats prevented the increase in systolic blood pressure by normalizing cytosolic [Ca 2+ ] i and kidney and aortic aldehyde...
The kidneys have long been considered the major site for 1α-hydroxylation of 25D to 1,25D. Unlike the loosely regulated hepatic hydroxylation of 25D, the renal 1α-hydroxylation falls under tight control of parathyroid hormone (PTH) and is primarily involved in calcium regulation and signaling...
Either way, they give rise to challenges, including poor targeting and systemic toxicity that can adversely affect multiple organs, like the heart and kidneys. Additionally, these treatments may promote infertility and, in extreme cases, mortality [3, 4]. The presence of such serious adverse ...