1,25 dihydroxyvitamin D 3 (1,25 (OH)2 D) and its less hypercalcemic analogues have been shown to inhibit the proliferation of vascular smooth muscle cells (VSMC) in culture. However, the mechanism(s) underlying this suppression is not well understood. Here we have shown that 1,25 (OH...
A regulatory mechanism for the vitamin D receptor (VDR) in rat osteosarcoma cells (ROS 17/2.8) is stabilization of the receptor through binding of its liga... NC Arbour,JM Prahl,DeLuca H F - 《Molecular Endocrinology》 被引量: 176发表: 1993年 Prolactin (PRL) receptor gene expression in ...
To evaluate levels of vitamin D3and HDL-cholesterol (HDL-C), and the ratio of HDL-C to LDL-cholesterol (LDL-C), in schoolchildren receiving vitamin-D-fortified, fat-depleted, high-Ca milk in schools. Cross-sectional study of previously randomised schools receiving supplemental milk, compared...
Vitamin D Vitamin D is unusual in that the human body can synthesize it through the skin when the exposed to sunlight. Because most people, particularly the elderly, spend much of their time indoors, studies have demonstrated nearly 60% of people over 70 are vitamin D deficient. Vitamin D ...
Since the ARs risk was also reported depending on the age, sex, VitD status of the individuals and the regimen administration, this limit should be investigated and related to the VitD therapeutic window [62]. In fact, data from observational studies evidenced a “V” trend of the curve ...
through the VDR stimulates transcription of genesencoding calciumtransport proteins(TRPV5/6), bonematrix proteins(osteopontin, osteocalcin),bone resorptionfactors (RANKL), and 25OHD-24-hydroxylase and represses those that encode PTH,PTHrP, and 25-hydroxyvitaminD-1α-hydroxylase. The calcitriol-VDR ...
In general, the expected number of exposures over a time window \((0,\tau ]\) is given by \(\int _{0}^{\tau } \lambda (t)\, \text {d} t\). For step intensity functions where \(\lambda (t)=\lambda _0\) for some interval of t values, this can conveniently be re-scaled...
Vitamin D3, which was also known as cholecalciferol, can be metabolized to produce 25-hydroxyvitamin D38. Vitamin D3 can be supplemented through sunlight and food intake9. Vitamin D3 acted as a vital substance in human body, many diseases, such as type 2 diabetes11, cancer12, autoimmune di...
1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3), the active metabolite of vitamin D, mediates many of its effects through the intranuclear vitamin D receptor (VDR, NR1I1), that belongs to the large superfamily of nuclear receptors. Vitamin D receptor can directly regulate gene expression by bi...
We then tested if the link between B12, H3K36me3 and reprogramming observed during in vitro reprogramming of MEFs could also be substantiated during in vivo reprogramming. First, we found that the mRNA levels ofSetd2, the gene encoding the only known mammalian methyltransferase that catalyses ...