Vitamin D Vitamin D is unusual in that the human body can synthesize it through the skin when the exposed to sunlight. Because most people, particularly the elderly, spend much of their time indoors, studies have demonstrated nearly 60% of people over 70 are vitamin D deficient. Vitamin D ...
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Repression and activation of vitamin D receptor (VDR)-mediated transcription. The transcription complex between VDR and the retinoid X receptor (RxR) in the presence of corepressors is not transcriptionally active. In the presence of agonists (VD3), VDR undergoes a conformation change through ...
3. Antioxidant Properties of Vitamin D Among its potential pleiotropic roles in human health, it has been suggested that the active form of vitamin D may act as a membrane antioxidant, protecting cell membranes against free radical-induced lipid peroxidation through interaction with phospholipid fatty...
Poor vitamin D status is a global health problem; insufficiency underpins higher risk of cancer, neurocognitive decline and all-cause mortality. Most foods contain little vitamin D and plants are very poor sources. We have engineered the accumulation of
While vitamin D (as cholecalciferol [vitamin D 3] or ergocalciferol [vitamin D2]) has a wide therapeutic window with a relatively low risk of toxicity, the easy availability of high-dose supplements (particularly on the internet) may increase the likelihood of such rare events in the...
In general, the expected number of exposures over a time window \((0,\tau ]\) is given by \(\int _{0}^{\tau } \lambda (t)\, \text {d} t\). For step intensity functions where \(\lambda (t)=\lambda _0\) for some interval of t values, this can conveniently be re-scaled...
Thus, this would indicate that 54.4% of the early regulated genes might in fact be secondary vitamin D target genes. The stringency of the prediction methods greatly depends on the window sizes that have been applied. For the FAIRE-seq motif and ChIP-seq approaches performed in TEPIC 2,...
Vitamin D3, which was also known as cholecalciferol, can be metabolized to produce 25-hydroxyvitamin D38. Vitamin D3 can be supplemented through sunlight and food intake9. Vitamin D3 acted as a vital substance in human body, many diseases, such as type 2 diabetes11, cancer12, autoimmune di...