These functions include the capacity to bind 1,25(OH)2D3, interact with partner proteins, associate specifically with unique DNA sequences upstream of vitamin D regulated genes, and activate transcription through contacts with the general transcriptional apparatus which assembles at initiator sequences....
In the second part, the structure-function relationship of vitamin D was analyzed based on the ligand struc-ture, in particular by using systematic conformational analysis as a tool. On the basis of the conformational analysis of the vitamin D side chain and studies using conformationally ...
structure-function relationship of vitamin D analogues through binding affinity for DBP and VDR in order to understand not only the detailed net work of the vitamin D3 endocrine system, but also the concept for the development of new drugs for treatment of osteoporosis, renal osteodystrophy and ...
Genome-Wide Perspectives on Vitamin D Receptor–Mediated Control of Gene Expression in Target Cells J. WesleyPike, ...Nancy A.Benkusky, inVitamin D (Fourth Edition), 2018 Overview of theVitamin DReceptor: The Protein, Its Structure, and Function146 ...
Structure and function of alpha-tocopherol transfer protein: implications for vitamin E metabolism and AVED. 来自 Semantic Scholar 喜欢 0 阅读量: 58 作者: C Min,K.摘要: Human alpha-tocopherol transfer protein (alpha-TTP) plays a central role in vitamin E homeostasis: mutations in the protein ...
The therapeutic approach to the management of corrosive burns of the upper gastrointestinal tract leaves a considerable morbidity and a heavy mortality rat... JD Costanzo,M Noirclerc,J Jouglard,... - Gut 被引量: 233发表: 1980年 Vitamin D: Structure‐function analyses and the design of analogs...
J. et al. Serum vitamin D and parathyroid hormone in relation to cardiac structure and function: the ICELAND-MI substudy of AGES-Reykjavik. J. Clin. Endocrinol. Metab. 98, 2544–2552 (2013). Article CAS PubMed PubMed Central Google Scholar van Ballegooijen, A. J. et al. Vitamin D...
In this review, the structure and function of the Gc protein is focused on especially with regard to Gc genotyping and GcMAF precursor activity. A discussion of the research strategy "GcMAF as a target for drug discovery" is included, based on our own research. 展开 ...
Structure-function studies of new C-20 primer pairs of vitamin D[sub3] analogs.Examines the structure-function of C-20 epimer of vitamin D[sub 3] analogs. Binding affinities of transcriptional coactivators; Description of the human vitamin D receptor; Use of northern blot analysis and ...
This causes the disturbances in vitamin D3 function and in activity of membrane-bound enzymes. The above mentioned changes and the increase of the atherogenicity coefficient allowed a conclusion to be made that rickets of children is ... LI Apukhovs,ka - 《Ukrainskiĭ Biokhimicheskiĭ Zhurna...