The serum concentration of 25(OH)D that is felt to constitute adequacy is a subject of much debate and the recommended threshold used to define VDD is highly variable between guidelines and consensus statements (Table1), and this can limit the comparison of reported prevalence between studies. T...
Randomized controlled trials have demonstrated that vitamin C replacement may not be sufficient to correct plasma vitamin C levels and resolve oxidative stress, adipose tissue inflammation, or features of metabolic syndrome in human obesity. Combining micronutrient supplementation and healthy whole-food ...
EFSA determined the Average Requirement (AR) for healthy adults based on the vitamin C intake that balanced losses as metabolic and urinary losses and the quantity of vitamin C required for the replacement of these losses to metabolic losses and maintained fasting plasma ascorbate concentrations at ...