Prolonged sun exposure alone cannot cause vitamin D overdose because sunlight destroys excess vitamin D3.(Kulie 2009) Toxicology Toxicity due to vitamin D is considered to manifest at levels greater than 150 ng/mL of serum 25(OH)D. Symptoms of hypervitaminosis D include fatigue, nausea, vomiti...
Vitamin D2 is also called “ergocalciferol.” It is not the form of vitamin D that you need to prevent cancer and degenerative diseases. The form of vitamin D which you need is vitamin D3 (“cholecalciferol”) and, as I mentioned above, it is produced from the UVB rays in sunlight. ...
sunlight has a downside in that the sunlight needs to be of useful strength in order for us to make vitamin D. At higher latitudes, the time and the amount of useful sunlight are short and low, respectively, during late autumn, winter and early spring. This means that body vitamin D ...
Maintaining an adequate level of vitamin D is essential for the normal functioning of the human body [1]. While this vitamin can also be obtained from dietary sources, it is mostly synthesized naturally in the human body under sunlight, hence frequently called the 'sunshine vitamin' [2]. When...
A plentiful supply of 7-dehydrocholesterol, the precursor of vitamin D3, exists in human skin and needs only to be activated by a moderate amount of ultraviolet light (less than a half hour of sunlight) to become fully potent. Rickets is usually caused by a lack of exposure to sunlight ...
groupand a double bond. Cholecalciferol is produced metabolically through a natural process of photolysis of 7-dehydrocholesterol on the surface of skin exposed toultraviolet irradiation, e.g., sunlight. Structures of ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3) are shown inFig. ...
In fact, alternative enzymatic reactions converting dienic sterols to vitamin D have been hypothesized in an attempt to explain the abundance of vitamin D in animals living out of sunlight reach such as deepsea fishes or subterranean mammals22. Likewise, the abundance of Δ5,7-cholesterol, ...
A systematic review showed that, despite relative abundance of sunlight avail- ability in the south Europe and east Mediterranean area, the average prevalence of circulating 25(OH)D concen- tration below 10 ng/mL ranged from 4 to 18%, while 25(OH)D concentration below 20 ng/mL ranged...
[17], which may be due to factors include limited sunlight exposure, reduced dietary VD and calcium intake, ethnicity, age, socio-economic status, smoking, repeated pregnancies, obesity, malabsorption syndromes, medications that increase vitamin D catabolism, and chronic liver and/or kidney disorders...
6d, e). Thus, ZK normalizes acute and chronic hypercalcemia induced by vitamin D3 intoxication. Fig. 6: ZK therapeutic effect in mice. a Schematic representation of 1,25D3 and ZK administration to mice. Serum calcium (b) and PTH (c) levels, and duodenal (d) and renal (e) relative ...