2. REGULATION OF VITAMIN D RECEPTOR ABUNDANCE Several studies have demonstrated that there is a strong correlation between the VDR level and the biological response in target cells [70]. A wide variety of factors, including PTH [71], pharmacological activators of the protein kinase A pathway [72...
mostly in the form of apatite crystals. In experimental animals, the administration of pharmacological doses of vitamin D sterols can lead to widespread arterial calcification, especially in association with favourable conditions such as atherosclerosis, diabetes and chronic kidney disease (CKD) [1-5]...
Hence, the hormone exerts various immunosuppressive effects that are evidenced in vivo by the fact that prophylactic 1,25-D3 treatments, performed at pharmacological doses, prevent the outcome of autoimmune diseases such as insulinitis or lupus erythematosus in genetically susceptible mice (Lemire et ...
Physiological Functions of Glucocorticoids in Stress and Their Relation to Pharmacological Actions* How the known physiological and pharmacological effects of glucocorticoids might accomplish this function, however, remains a mystery. A generalization that is ... M Allan,PM Guyre,NJ Holbrook - 《...
Pharmacological action Yes Actions Cofactor General Function Zinc ion binding Specific Function Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofola... Gene Name...
hypophosphatemia, multiple pseudofractures in typical cases, and response to treatment with pharmacological dose of vitamin D with or without phosphate ... K Konishi,M Nakamura,H Yamakawa,... - 《American Journal of the Medical Sciences》 被引量: 61发表: 1991年 ...
OBJECTIVE To summarize the studies of vitamin C in the treatment of tumor. METHODS This review,discussed the present research advances of vitamin C,including its pharmacokinetics,pharmacological mechanism,application in clinical medicine,some derivatives of vitamin C and their anticancer effect. RESULTS an...
fluorescent nutrient analogues, mitochondrial dyes, measurement of oxygen consumption and in-depth, mass-spectrometry based metabolic tracing of isotope-labelled nutrients. Specific metabolic pathways will be linked to defined immunological phenotypes and inflammatory functions using established pharmacological ...
The compounds of the present invention can be administered in any appropriate pharmacological carrier for topical or intravenous administration. The dosage administered will be dependent on the age, health and weight of the recipient, and the nature of the effect desired. ...
In their review article "Vitamin D and evolution: Pharmacologic implications," Hanel and Carlberg demonstrate that the pleiotropy of vitamin D signaling has an evolutionary origin, the understanding of which will allow a better use of the pharmacological potential of vitamin D and its derivatives. ...