Vitamin D (VitD) is a hormone naturally produced by mammalian cells in a coordinated manner by the skin, liver, and kidneys. VitD deficiency or insufficiency is prevalent in patients with CKD, and serum levels of VitD are inversely correlated with the degree of kidney ...
Vitamin D3(cholecalciferol) is synthesized in the skin by transformation of 7-dehydrocholesterol exposed to ultraviolet B rays of the sun. Vitamin D binding protein transports D3to the liver, where it is hydroxylated to the inactive 25(OH)D form (calcidiol). In the kidneys, it is further...
the kidneys and the skin but higher than in most other organs (Fig.1A). In another public transcriptomic database (GSE117261), VDR lung expression was downregulated in PAH-patients compared to controls (Fig.1B,
The livers and kidneys from adult beagle dogs chronically exposed to 1,1,1-trichloro-2,2-bis(-chlorophenyl)ethane (DDT) and from their Fweanling progeny were analyzed for vitamin A content. The dogs, subjects of a multigeneration study of the effects of DDT on canine reproduction, were fed...
Klotho is an anti-aging protein that is mostly secreted by the kidneys, the brain, and the thyroid. It plays a significant role in regulating kidney function and vascular health. Klotho gene is named after “the Spinner” (Clotho from Greek mythology), the goddess who spins the thread of ...
M Cozzolino,M Ketteler,D Zehnder - 《European Journal of Heart Failure》 被引量: 71发表: 2014年 The immune system and kidney disease: basic concepts and clinical implications The kidneys are frequently targeted by pathogenic immune responses against renal autoantigens or by local manifestations of...
These include the immunomodulatory effects on the innate and adaptive immune systems, the regulatory effects on the renin-angiotensin-aldosterone-system in the kidneys and the lungs, and the protective effects against endothelial dysfunction and thrombosis. Prior to the COVID-19 pandemic, studies have...
The vitamin D hormone 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) is generated by a series of hydroxylation steps in the liver and kidneys. We investigated whether naturally vitamin D-deficient subterranean mammals (naked mole rats, Heterocephalus glaber) employ the same enzymatic pathways, and wheth...
Due to old age and because the skin is not able to synthesize vitamin D efficiently, older adults are at a greater risk of developing a vitamin D deficiency. As people get older, their skin does not produce much vitamin D as a reaction to sun exposure. Simultaneously, their kidneys will ...
25-OHD is the major circulating metabolite and the recommended biomarker used to measure vitamin D status due to its stability and long half-life7,8. 25-OHD is converted by the kidneys into the active form 1,25-hydroxyvitamin D, which interacts via the vitamin D receptor, a nuclear ...