VITAMIN DRENAL fibrosisChronic kidney disease (CKD) has been recognized as a significant global health problem due to being an important contributor to morbidity and mortality. Inflammation is the critical event that leads to CKD development orchestrated by a complex interaction ...
In chronic kidney disease (CKD), abnormalities in vitamin D metabolism contribute to the development of mineral and skeletal disorders, elevations in parathyroid hormone (PTH), hypertension, systemic inflammation, renal and cardiovascular damage. CKD induces a progressive loss of the capacity of the ...
Chronic kidney diseaseFGF23HyperplasiaParathyroid hormonePhosphorusSecondary hyperparathyroidismVitamin DVitamin D receptorParathyroid glands have a predominant role in mineral homeostasis. Calcium and vitamin D are two of the main regulators of the parathyroid function by virtue of the presence of the ...
Although the presence of hypovitamin D increases the risk of rickets and fractures, low vitamin D levels are also associated with hypertension, cancer, and cardiovascular disease. In addition, diabetes mellitus (DM) and chronic kidney disease (CKD) are also related to vitamin D levels. Vitamin ...
Vitamin D shows promise for improving diverse health outcomes among patients with chronic kidney disease. Observational studies of vitamin D medications have contributed important evidence for broad beneficial clinical effects of vitamin D beyond actions on bone. However, such studies are limited by the...
Chronic kidney disease is usually complicated with deficiency of vitamin D which causes severe impairment of kidney function through stimulating RAS(renin-angiotensin system)and other pathways.Both in vivo and in vitro studies have demonstrated that active vitamin D and its analogues supplementation may ...
Methods In the frame of a randomized, double-blind, placebo controlled trial, the Paracalcitol and ENdothelial fuNction in chronic kidneY disease (PENNY), we investigated whether vitamin D receptor activation by paricalcitol (2 μg/day ... T Claudia,P Patrizia,C Sebastiano,... - 《Plos One...
and cardiovascular disease.In addition,diabetes mellitus(DM) and chronic kidney disease(CKD) are also related to vitamin D levels.Vitamin D deficiency has been linked to onset and progression of DM.Although in patients with DM the relationship between vitamin D and insulin secretion,insulin ...
Vitamin D deficiency is highly prevalent among patients with chronic kidney disease (CKD). The benefits and harms of vitamin D supplementation (ergocalciferol or cholecalciferol) were assessed in patients with nondialysis-dependent CKD, dialysis-dependent CKD, and renal transplant recipients.MEDLINE (196...
Chronic kidney disease Eating disorders (eg,anorexia nervosa) Medical conditions that affect absorption of vitamin D from the diet (such asCeliac diseaseor pancreatic insufficiency) Prolonged, exclusive breastfeeding or being born to a vitamin D deficient mother ...