Dual role of vitamin C in an oxygen-sensitive system: discrepancy between DNA damage and cell death. Free Radic Res. 2005; 39 :213–220. [ PubMed ]Shi M, Xu B, Azakami K, Morikawa T, Watanabe K, Morimoto K, Komatsu M, Aoyama K, Takeuchi T: Dual role of vitamin C in an ...
Guaiquil VH, Vera JC, Golde DW. Mechanism of vitamin C inhibition of cell death induced by oxidative stress in glutathione-depleted HL-60 cells. J Biol Chem 2001;276:40955–40961. ArticlePubMedCASGoogle Scholar Jackson JH, Gajewski E, Schraufstatter IU, et al. Damage to the bases in D...
When GSH-depleted cells were exposed to high concentrations (50 µm) of H2O2, however, cell survival decreased to 50% after 4 h of incubation (data not shown). Concentrations of H2O2 higher than 100 µm induced rapid cell death, and vitamin C had little effect on cell survival (Fig....
In homeostasis, vitamin C regulates the balance between self-renewal, differentiation, and cell death of hematopoietic stem cells and multipotent progenitors (HSC/MPPs) by promoting Tet2 activity. In contrast, vitamin C depletion accelerates leukemogensis of Tet2-mutant leukemic stem cells (LSCs) and...
cell death in liver cancer cells and the response to VC was correlated with sodium-dependent vitamin C transporter 2 (SVCT-2) expressions. Mechanistically, VC uptake via SVCT-2 increased intracellular ROS, and subsequently caused DNA damage and ATP depletion, leading to cell cycle arrest and ...
Vitamin D is a fat-soluble vitamin that our skin synthesizes when exposed to the sun. It benefits us in many ways, from bone health to mood.
In Escherichia coli, a common mechanism of cell death by bactericidal antibiotics involves the generation of highly reactive hydroxyl radicals via the Fenton reaction. Here we show that vitamin C, a compound known to drive the Fenton reaction, sterilizes cultures of drug-susceptible and drug-...
In contrast, shRNA-mediated depletion of essential components of MutS or MutL mismatch repair complexes greatly improved survival of all Cr-treated cells and eliminated Asc-potentiated effects on cell death. Thus, mismatch repair-mediated enhancement of Cr(VI) cytotoxicity by Asc should promote the ...
Water Solubility <0.1 g/L (20 ºC) Sensitive Air & Light Sensitive Merck 14,10019 BRN 2339331 Stability Light Sensitive, Temperature Sensitive InChIKey QYSXJUFSXHHAJI-YRZJJWOYSA-N LogP 9.085 (est) FDA 21 CFR 310.545 CAS DataBase Reference 67-97-0(CAS DataBase Reference) SC...
Vitamin A1 (VA1), Molecular formula, C20H30O; MW, 286.45; CAS, 68-26-8. Melting point: 62–64 °C. Boiling point: 137–138 °C VA2, Molecular formula, C20H28O; MW, 284.44; Melting point: 17–19 °C. Originator Acon ,Endo ...