C. eleganscell lineagedevelopmental apoptosisengulfmentgermline apoptosisDNA damage‐induced apoptosisSignificance: Persistent oxidative stress is a common feature of cancer cells, giving a specific weapon to selectively eliminate them. Ascorbate in pharmacologic concentration can contribute to the suspended ...
When GSH-depleted cells were exposed to high concentrations (50 µm) of H2O2, however, cell survival decreased to 50% after 4 h of incubation (data not shown). Concentrations of H2O2 higher than 100 µm induced rapid cell death, and vitamin C had little effect on cell survival (Fig....
In vitro and in vivo experiments further demonstrated that clinically achievable concentrations of VC induced cell death in liver cancer cells and the response to VC was correlated with sodium-dependent vitamin C transporter 2 (SVCT-2) expressions. Mechanistically, VC uptake via SVCT-2 increased ...
Guaiquil VH, Vera JC, Golde DW. Mechanism of vitamin C inhibition of cell death induced by oxidative stress in glutathione-depleted HL-60 cells. J Biol Chem 2001;276:40955–40961. Article Jackson JH, Gajewski E, Schraufstatter IU, et al. Damage to the bases in DNA induced by stimulate...
Low vitamin C and increased oxidative stress and cell death in mice that lack the sodium-dependent vitamin C transporter SVCT2. The sodium-dependent vitamin C transporter (SVCT2) is responsible for the transport of vitamin C into cells in multiple organs, from either the blood or the ...
In homeostasis, vitamin C regulates the balance between self-renewal, differentiation, and cell death of hematopoietic stem cells and multipotent progenitors (HSC/MPPs) by promoting Tet2 activity. In contrast, vitamin C depletion accelerates leukemogensis of Tet2-mutant leukemic stem cells (LSCs) and...
In contrast, shRNA-mediated depletion of essential components of MutS or MutL mismatch repair complexes greatly improved survival of all Cr-treated cells and eliminated Asc-potentiated effects on cell death. Thus, mismatch repair-mediated enhancement of Cr(VI) cytotoxicity by Asc should promote the ...
vitamin C-treated KO-Tg mice indicates an increase in the number of TJ proteins and the transport of various molecules. Oxidative stress has a key role in the pathogenesis of the AD, contributing to the degeneration of the basal forebrain cholinergic system and general cell death.41,42AD ...
4/11/2013 - A lack of education kills more people than cancer, heart disease and conventional medicine combined. Would we really see so much death and destruction if the majority of the people really knew about the value of fresh, clean food, water and air? And, if people really knew th...
vitamin C-induced up-regulation of heme-oxygenase-1 and ferritin inKRAS-mutant cancer cells, consequently increasing reactive iron, oxygen species, and cell death; an effect further potentiated by chemotherapy. In support of a potential role of ferritin in colorectal cancer progression, an analysis ...