In the present study, we evaluated the mode of action of vitamin B6 by microarrays. We interpreted the transcriptomic data using biological system based analysis rather than a “gene by gene” approach. The Gene Ontology (GO) [11] and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathwa...
Cellular metabolism is a system of chemical reactions in which cells harness the energy stored in the chemical bonds of substrate molecules to perform their biological functions, maintain homeostasis, or to synthesize building blocks for structural maintenance or cellular division. The kinetics of these ...
通过进一步预测差异表达miRNAs的靶基因, 对预测的靶基因进行GO和KEGG富集分析, 鉴定出miR-194a的靶基因jak2a与tyk2富集在JAK-STAT信号通路中, 而该通路对造血、免疫、脂质代谢及细胞的增殖分化与迁移至关重要[26], 因此将miR-194a与其靶基因jak2a与tyk2作为本研究的重点。 miRNA的功能一般需要通过对靶基因进行生物...
against KEGG database. KEGG enrichment analysis indicated that most of the variable genes were associated with the following biological processes: “microbial metabolism in diverse environments”, “biosynthesis of antibiotics”, “carbon metabolism”, “two–component system”, “biosynthesis of amino aci...
(Fig.5a). A KEGG pathway analysis identified four pathways that were significantly enriched in the differentially changed metabolites, and these included the vitamin B6metabolism pathway due to the decreased relative abundances of pyridoxamine (PM) and pyridoxal 5′-phosphate (PLP) in the PFC of ...
The kinetics and localization of the reactions of metabolism are coordinated by the enzymes that catalyze them. These enzymes are controlled via a myriad of mechanisms including inhibition/activation by metabolites, compartmentalization, thermodynamics,
(This article belongs to the Special IssueMolecular Advances in Cancer and Cell Metabolism) Downloadkeyboard_arrow_down Browse Figures Versions Notes Abstract Glioblastoma (GBM) is a deadly brain cancer. The prognosis of GBM patients has marginally improved over the last three decades. The response ...
Therefore, a combination of B-group vitamins should be more effective than supplementation with B6, B12, or folate alone, as they are all involved in methyl metabolism. 4.1.1. Vitamin B1 (Thiamin) Vitamin B1, also known as thiamin, plays a critical role in the function of the neurological...
These results affirm the PBS’s impact on the BPs crucial to DNA integrity and ROS metabolism, further substantiating the biological relevance of the PBS in these pathways. Within the multi-layered framework of the CODA network, compound-target associations offer insights into the primary biological...
Vitamin A has three active forms (retinal, retinol and retinoic acid), and vitamin A metabolism can be classified into three major processes—intestinal uptake (especially small intestine), hepatic storage and lymphatic and blood transport to supply the body's physiological needs [10]. However, ...