It can correct for pleiotropy using robust adjusted profile scores and is recommended to routinely use the RAPS estimator in practice, especially if the exposure and the outcome are both complex traits. Analyses were performed using R version 4.1.2 (R Foundation for Statistical Computing, Vienna, ...
In vivo, vitamin B12deficiency yields a complex phenotype because it impacts multiple cellular processes and organ functions26. Therefore, we asked whether the effect of B12on reprogramming could be recapitulated in vitro. We first observed, in a previously published bulk RNA-seq dataset of MEFs un...
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Both the habitual diet and blood levels of B vitamins used in this study are within the normal ranges expected for humans. As such, in future a stratified analysis of the levels of B vitamins could reveal additional metabolic and epigenetic signatures of interest. Additionally, the discovery phas...
Using Arabidopsis mutant plants defective in abscisic acid production, we demonstrate that this phytohormone is important in the regulation of THI1 and THIC gene expression during salt stress but that the regulatory mechanisms underlying the osmotic stress response are more complex. Conclusions On the ...
Vitamin D is a fat-soluble vitamin that our skin synthesizes when exposed to the sun. It benefits us in many ways, from bone health to mood. Dosage Examine Database Research feedShare Vitamin D is most often used for Immunity & Infectious Disease. The Examine Database covers Multiple Sclero...
Some of the unexplained findings associated with vitamin D deficiency and other diseases may be attributable to the above-mentioned epigenetic changes in vitamin D and its enzyme system, as well as toxic and nutritional influences (e.g., changes in vitamin D, vitamin B-complex status, VDR polym...
B vitamins in the one-carbon metabolism pathway (folate, vitamin B6, and vitamin B12) have been implicated in DNA methylation, and their deficiency may contribute to cognitive decline through increased homocysteine (Hcy) levels and subsequent oxidative d
simulation of an individual’s vitamin D status profile (introduced in “Modelling individual vitamin D status trajectories”) 2. simulation of times of exposure (to infection in this example) 3. get probability of developing illness conditional on vitamin D status at exposure 4. simulation of...
(b, c). *P < 0.05; **P < 0.01; two-tailed Student’s t-test (b, c). Source Data Extended Data Fig. 7 DNA methylation defects in E13.5 vitamin-C-deficient female germ cells. a, Average methylation of cytosine according to sequence context. Genome-wide CpG methylation is 3–6% ...