Abdominal surgery may cause Cbl deficiency in several ways: gastrectomy eliminates the site of intrinsic factor production; blind loop syndrome results in competition for vitamin B-12 by bacterial overgrowth in the lumen of the small intestine; and surgical resection of the ileum eliminates the site ...
palmitoyl transferasesCPT1A,CPT1B, andCPT1Ccross the inner mitochondrial membrane through the solute carrierSLC25A20[152]. Vitamin C similarly serves as a cofactor for tyrosine hydroxylase (TH), which catalyzes the first reaction in catecholamine (e.g. dopamine, epinephrine, and norepinephrine) sy...
Injection of HNF4α-overexpressing AAV significantly up-regulated hepatic expressions of HNF4α and its downstream molecules, MTTP and ApoB, in mice (Fig. 7A). Overexpression of HNF4α significantly restored fasting serum glucose, insulin, and HOMA-IR values (Fig. 7, B–D) and reduced ...
fasted for 16 h, and given quetiapine (10 mg/kg, i.p.) or vehicle 30 min before injection ofd-glucose (3 g/kg, i.p.). (a) Blood glucose (n = 14) and (b) blood insulin (n = 8) levels were measured at the indicated times. Data are given ...
palmitoyl transferasesCPT1A,CPT1B, andCPT1Ccross the inner mitochondrial membrane through the solute carrierSLC25A20[152]. Vitamin C similarly serves as a cofactor for tyrosine hydroxylase (TH), which catalyzes the first reaction in catecholamine (e.g. dopamine, epinephrine, and norepinephrine) ...
Increased diarrhea incidence and damaged intestinal morphology were observed in piglets following CPT-11 injection. As shown in Figure 1A, CPT significantly decreased average daily weight gain (ADG) and increased diarrhea incidence. The H&E-stained images in Figure 1B,C exhibited the decreased villou...
Although a non-invasive injection is preferred, this requires the solidification of the gel in vivo when exposed to endogenous stimuli, which is sometimes troublesome. Nevertheless, there has been recent developments in light-responsive agents for targeted therapies using vitamin B12 as the ultimate ...
In most Western countries, a single prophylactic intramuscular injection of vitamin K is administered at birth and greatly reduces the rate of the hemorrhagic disease of the newborn [6]. In vertebrates, the only well-described cellular function of vitamin K is to support γ-glutamyl carboxylation...