136, 137 Generally, RNA-containing viruses, including influenza virus, measles virus, poliovirus, reovirus, and Sindbis virus, induce apoptosis of host cells, whereas DNA-containing viruses, including adenovirus, CMV, EBV, HPV, and the poxviruses, encode proteins that block apoptosis. For some ...
In fact, one strategy to enhance the tumor cell specificity of oncolytic viruses is to mutate them to induce a more potent IFN response [52]. While this reduces the replication of such viruses in normal cells, cancer cells remain permissive to the viruses because they are unable to respond ...
Targeted Oncolytic Adenovirus for Human Cancer Therapy: Gene-Based Therapies for Cancer Replication-selective tumor-specific viruses represent a novel approach for the treatment of neoplastic disease. These vectors are designed to induce viru... T Fujiwara 被引量: 8发表: 1970年 加载更多来源...
The ability of viruses to target cancer cells arises from their exploitation of the aberrant signaling path- ways and the generally poor antiviral response produced by cancer cells [126]. Many viruses are able to induce lysis of cancer cells in vitro but their effect in vivo appears ...
First, viruses can directly induce transformation of the infected cells. The genes that virus- es express following integration or after establishing a stable episome can regulate host cell growth and surviv- al. Alternatively, recognition of viral genes by host cells can initiate the DNA damage ...
The finding that BMV 1a parallels Gag in acting at high mul- tiplicity to induce the RNA-replication compartment (FIG. 4a,b) implies that such polymerase downregula- tion might satisfy functional requirements similar to those governing the Gag/Gag–Pol ratio in retrovirus capsids. Like ...
which can trigger an immune response against the neo-antigen. If new T cell clones are generated, they may be able to circulate and kill antigen-expressing cancer cells, including cancer cells that were not infected by the virus. The immune response has also been associated with a 'immune-as...
Unexpectedly, certain combinations of functional F and H proteins were unable to induce syncytium formation, an observation suggesting that specific F-H protein interactions are required for cell fusion. We also found that three of four H proteins of persistent MVs are defective in intracellular ...
simplex virus type 1 (HSV-1) encoding granulocyte–macrophage colony stimulating factor (GM-CSF), termed talimogene laherparepvec (T-VEC), by the US Food and Drug Administration (FDA) in the United States is likely to promote further drug development within this new class of cancer ...
Cesur O, Nicol C, Groves H, Mankouri J, Blair GE and Stonehouse NJ: The subcellular localisation of the human papil- lomavirus (HPV) 16 E7 protein in cervical cancer cells and its pert...